Manu Ben-Johny
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Explore the profile of Manu Ben-Johny including associated specialties, affiliations and a list of published articles.
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42
Citations
786
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Recent Articles
1.
Hussey J, DeMarco E, DiSilvestre D, Brohus M, Busuioc A, Iversen E, et al.
bioRxiv
. 2024 Dec;
PMID: 39677635
Calmodulinopathies are caused by mutations in calmodulin (CaM), and result in debilitating cardiac arrythmias such as long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, many patients exhibit...
2.
Del Rivero Morfin P, Chavez D, Jayaraman S, Yang L, Geisler S, Kochiss A, et al.
Sci Adv
. 2024 Oct;
10(44):eadq3374.
PMID: 39475605
L-type Ca channels (Ca1.2/1.3) convey influx of calcium ions that orchestrate a bevy of biological responses including muscle contraction, neuronal function, and gene transcription. Deficits in Ca1 function play a...
3.
Fossier L, Ben-Johny M
Nat Cardiovasc Res
. 2024 Aug;
2(6):494-495.
PMID: 39195887
No abstract available.
4.
Wright K, Nathan S, Jiang H, Xia W, Kim H, Chakouri N, et al.
J Biol Chem
. 2024 Feb;
300(3):105715.
PMID: 38309503
NEDD4L is a HECT-type E3 ligase that catalyzes the addition of ubiquitin to intracellular substrates such as the cardiac voltage-gated sodium channel, Na1.5. The intramolecular interactions of NEDD4L regulate its...
5.
Papa A, Del Rivero Morfin P, Chen B, Yang L, Katchman A, Zakharov S, et al.
J Clin Invest
. 2024 Jan;
134(5).
PMID: 38227371
The ability to fight or flee from a threat relies on an acute adrenergic surge that augments cardiac output, which is dependent on increased cardiac contractility and heart rate. This...
6.
Del Rivero Morfin P, Kochiss A, Liedl K, Flucher B, Fernandez-Quintero M, Ben-Johny M
J Gen Physiol
. 2024 Jan;
156(2).
PMID: 38175169
Voltage-dependent and Ca2+-dependent inactivation (VDI and CDI, respectively) of CaV channels are two biologically consequential feedback mechanisms that fine-tune Ca2+ entry into neurons and cardiomyocytes. Although known to be initiated...
7.
Del Rivero Morfin P, Chavez D, Jayaraman S, Yang L, Kochiss A, Colecraft H, et al.
bioRxiv
. 2023 Oct;
PMID: 37790372
L-type Ca channels (Ca 1.2/1.3) convey influx of calcium ions (Ca ) that orchestrate a bevy of biological responses including muscle contraction and gene transcription. Deficits in Ca 1 function...
8.
Del Rivero Morfin P, Kochiss A, Liedl K, Flucher B, Fernandez-Quintero M, Ben-Johny M
bioRxiv
. 2023 Oct;
PMID: 37790368
Voltage-dependent and Ca-dependent inactivation (VDI and CDI, respectively) of Ca channels are two biologically consequential feedback mechanisms that fine-tune Ca entry into neurons and cardiomyocytes. Although known to be initiated...
9.
10.
Feldmann C, Schanzler M, Ben-Johny M, Wahl-Schott C
STAR Protoc
. 2023 Jul;
4(3):102459.
PMID: 37516972
Two-hybrid Förster resonance energy transfer (FRET) provides proximity, affinity, and stoichiometry information in binding interactions. We present an image-based approach that surpasses traditional two-hybrid FRET assays in precision and robustness....