Nourdine Chakouri
Overview
Explore the profile of Nourdine Chakouri including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
101
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Wright K, Nathan S, Jiang H, Xia W, Kim H, Chakouri N, et al.
J Biol Chem
. 2024 Feb;
300(3):105715.
PMID: 38309503
NEDD4L is a HECT-type E3 ligase that catalyzes the addition of ubiquitin to intracellular substrates such as the cardiac voltage-gated sodium channel, Na1.5. The intramolecular interactions of NEDD4L regulate its...
2.
Chakouri N, Rivas S, Roybal D, Yang L, Diaz J, Hsu A, et al.
Nat Cardiovasc Res
. 2022 Jun;
1(5):1-13.
PMID: 35662881
Voltage-gated sodium (Nav1.5) channels support the genesis and brisk spatial propagation of action potentials in the heart. Disruption of Na1.5 inactivation results in a small persistent Na influx known as...
3.
Kschonsak M, Chua H, Weidling C, Chakouri N, Noland C, Schott K, et al.
Nature
. 2021 Dec;
603(7899):180-186.
PMID: 34929720
Depolarizing sodium (Na) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion and pain sensitivity. NALCN requires FAM155A,...
4.
Rivas S, Hanif K, Chakouri N, Ben-Johny M
Methods Enzymol
. 2021 Jun;
653:319-347.
PMID: 34099178
Ion channels are macromolecular complexes whose functions are exquisitely tuned by interacting proteins. Fluorescence resonance energy transfer (FRET) is a powerful methodology that is adept at quantifying ion channel protein-protein...
5.
Kang P, Chakouri N, Diaz J, Tomaselli G, Yue D, Ben-Johny M
Proc Natl Acad Sci U S A
. 2021 May;
118(21).
PMID: 34021086
In cardiomyocytes, Na1.5 channels mediate initiation and fast propagation of action potentials. The Ca-binding protein calmodulin (CaM) serves as a de facto subunit of Na1.5. Genetic studies and atomic structures...
6.
Hedon C, Lambert K, Chakouri N, Thireau J, Aimond F, Cassan C, et al.
Prog Biophys Mol Biol
. 2020 Oct;
159:105-117.
PMID: 33031824
The transient receptor potential Melastatin 4 (TRPM4) channel is a calcium-activated non-selective cation channel expressed widely. In the heart, using a knock-out mouse model, the TRPM4 channel has been shown...
7.
Abrams J, Roybal D, Chakouri N, Katchman A, Weinberg R, Yang L, et al.
JCI Insight
. 2020 Sep;
5(19).
PMID: 32870823
The Ca2+-binding protein calmodulin has emerged as a pivotal player in tuning Na+ channel function, although its impact in vivo remains to be resolved. Here, we identify the role of...
8.
Chakouri N, Diaz J, Yang P, Ben-Johny M
J Biol Chem
. 2020 Aug;
295(44):14948-14962.
PMID: 32820053
Calmodulin (CaM) regulation of voltage-gated calcium (Ca1-2) channels is a powerful Ca-feedback mechanism to adjust channel activity in response to Ca influx. Despite progress in resolving mechanisms of CaM-Ca feedback,...
9.
Chakouri N, Farah C, Matecki S, Amedro P, Vincenti M, Saumet L, et al.
Theranostics
. 2020 Jul;
10(18):8130-8142.
PMID: 32724462
Anthracyclines are key chemotherapeutic agents used in various adult and pediatric cancers, however, their clinical use is limited due to possible congestive heart failure (HF) caused by acute and irreversible...
10.
Chakouri N, Reboul C, Boulghobra D, Kleindienst A, Nottin S, Gayrard S, et al.
Int J Cardiol
. 2018 Mar;
258:207-216.
PMID: 29544934
Background: The interplay between oxidative stress and other signaling pathways in the contractile machinery regulation during cardiac stress and its consequences on cardiac function remains poorly understood. We evaluated the...