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Manjula Vinod

Explore the profile of Manjula Vinod including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 173
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Recent Articles
1.
Berthier A, Gheeraert C, Vinod M, Johanns M, Guille L, Haas J, et al.
J Hepatol . 2025 Feb; PMID: 39947330
Background: Metabolic flexibility (MetF) is an organism's ability to adjust to changing metabolic supplies and energy demands. Insulin plays a central role in coordinating MetF through molecular mechanisms such as...
2.
Vinod M, Berthier A, Marechal X, Gheeraert C, Boutry R, Delhaye S, et al.
Nat Cardiovasc Res . 2024 Jan; 1(11):990-1005. PMID: 38229609
Myocardial ischemia-reperfusion injury (MIRI) induces life-threatening damages to the cardiac tissue and pharmacological means to achieve cardioprotection are sorely needed. MIRI severity varies along the day-night cycle and is molecularly...
3.
Berthier A, Gheeraert C, Johanns M, Vinod M, Staels B, Eeckhoute J, et al.
J Biol Rhythms . 2023 Oct; 39(1):20-34. PMID: 37872767
Circadian-paced biological processes are key to physiology and required for metabolic, immunologic, and cardiovascular homeostasis. Core circadian clock components are transcription factors whose half-life is precisely regulated, thereby controlling the...
4.
Zummo F, Berthier A, Gheeraert C, Vinod M, Bobowski-Gerard M, Molendi-Coste O, et al.
J Mol Endocrinol . 2023 Mar; 71(1). PMID: 36988391
The functional versatility of the liver is paramount for organismal homeostasis. Adult liver functions are controlled by a tightly regulated transcription factor network including nuclear receptors (NRs), which orchestrate many...
5.
Dubois V, Gheeraert C, Vankrunkelsven W, Dubois-Chevalier J, Dehondt H, Bobowski-Gerard M, et al.
Mol Syst Biol . 2020 May; 16(5):e9156. PMID: 32407006
Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute induction of genes involved in handling of endoplasmic...
6.
Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, et al.
Proc Natl Acad Sci U S A . 2018 Nov; 115(47):E11033-E11042. PMID: 30397120
The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as...
7.
Chinetti-Gbaguidi G, Daoudi M, Rosa M, Vinod M, Louvet L, Copin C, et al.
Circ Res . 2017 Apr; 121(1):19-30. PMID: 28438779
Rationale: Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and...
8.
Vinod M, Patankar J, Sachdev V, Frank S, Graier W, Kratky D, et al.
Am J Physiol Endocrinol Metab . 2016 May; 311(1):E175-E185. PMID: 27221121
Glucose homeostasis is a complex indispensable process, and its dysregulation causes hyperglycemia and type 2 diabetes mellitus. Glucokinase (GK) takes a central role in these pathways and is thus rate...
9.
De Paoli F, Copin C, Vanhoutte J, Derudas B, Vinod M, Zawadzki C, et al.
FEBS Lett . 2016 Jan; 590(1):43-52. PMID: 26763127
Macrophages display heterogeneous phenotypes, including the classical M1 proinflammatory and the alternative M2 anti-inflammatory polarization states. The transducin-like enhancer of split-1 (TLE1) is a transcriptional corepressor whose functions in macrophages...
10.
Vinod M, Chennamsetty I, Colin S, Belloy L, De Paoli F, Schaider H, et al.
Biochim Biophys Acta . 2014 Mar; 1841(6):827-35. PMID: 24603323
Liver X receptors (LXRα and LXRβ) are key transcription factors in cholesterol metabolism that regulate cholesterol biosynthesis/efflux and bile acid metabolism/excretion in the liver and numerous organs. In macrophages, LXR...