Manjula Pandey
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Explore the profile of Manjula Pandey including associated specialties, affiliations and a list of published articles.
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21
Citations
574
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Recent Articles
11.
Sun B, Johnson D, Patel G, Smith B, Pandey M, Patel S, et al.
Nature
. 2011 Sep;
478(7367):132-5.
PMID: 21927003
Helicases are vital enzymes that carry out strand separation of duplex nucleic acids during replication, repair and recombination. Bacteriophage T7 gene product 4 is a model hexameric helicase that has...
12.
Patel S, Pandey M, Nandakumar D
Curr Opin Chem Biol
. 2011 Aug;
15(5):595-605.
PMID: 21865075
Helicases are molecular motor proteins that couple NTP hydrolysis to directional movement along nucleic acids. A class of helicases characterized by their ring-shaped hexameric structures translocate processively and unidirectionally along...
13.
Patel G, Johnson D, Sun B, Pandey M, Yu X, Egelman E, et al.
J Biol Chem
. 2011 Apr;
286(23):20490-9.
PMID: 21515672
The helicase and primase activities of the hexameric ring-shaped T7 gp4 protein reside in two separate domains connected by a linker region. This linker region is part of the subunit...
14.
Pandey M, Levin M, Patel S
Methods Mol Biol
. 2010 Mar;
587:57-83.
PMID: 20225142
DNA unwinding and polymerization are complex processes involving many intermediate species in the reactions. Our understanding of these processes is limited because the rates of the reactions or the existence...
15.
Pandey M, Syed S, Donmez I, Patel G, Ha T, Patel S
Nature
. 2009 Nov;
462(7275):940-3.
PMID: 19924126
Genomic DNA is replicated by two DNA polymerase molecules, one of which works in close association with the helicase to copy the leading-strand template in a continuous manner while the...
16.
Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis V, et al.
J Cell Biol
. 2008 Jun;
181(7):1211-22.
PMID: 18573917
Platelet aggregation requires agonist-induced alphaIIbbeta3 activation, a process mediated by Rap1 and talin. To study mechanisms, we engineered alphaIIbbeta3 Chinese hamster ovary (CHO) cells to conditionally express talin and protease-activated...
17.
Pandey M, Patel S, Gabriel A
PLoS One
. 2008 Jan;
3(1):e1389.
PMID: 18167548
DNA and RNA polymerases use a common phosphoryl transfer mechanism for base addition that requires two or three acidic amino acid residues at their active sites. We previously showed, for...
18.
Neels J, Pandey M, Hotamisligil G, Samad F
Am J Pathol
. 2006 Jan;
168(2):435-44.
PMID: 16436658
Although tumor necrosis factor-alpha (TNF-alpha) is elevated in adipose tissue in obesity and may contribute to the cardiovascular and metabolic risks associated with this condition, the mechanisms leading to elevated...
19.
Pandey M, Loskutoff D, Samad F
FASEB J
. 2005 Jun;
19(10):1317-9.
PMID: 15928193
Increased expression of plasminogen activator inhibitor -1 (PAI-1) in adipose tissues is thought to contribute to both the cardiovascular and metabolic complications associated with obesity. Tumor necrosis factor alpha (TNF-alpha)...
20.
Pandey M, Patel S, Gabriel A
J Biol Chem
. 2004 Aug;
279(46):47840-8.
PMID: 15333632
Long terminal repeat-containing retrotransposons encode reverse transcriptases (RTs) that replicate their RNA into integratable, double-stranded DNA. A mutant version of the RT from Saccharomyces cerevisiae retrotransposon Ty1, in which one...