Gokhan S Hotamisligil
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Explore the profile of Gokhan S Hotamisligil including associated specialties, affiliations and a list of published articles.
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32590
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Recent Articles
1.
Yuan B, Doxsey W, Tok O, Kwon Y, Liang Y, Inouye K, et al.
Cell Metab
. 2025 Feb;
PMID: 39983714
Mammalian tissues feed on nutrients in the blood circulation. At the organism level, mammalian energy metabolism is comprised of the oxidation, storage, interconversion, and release of circulating nutrients. Here, by...
2.
Baazim H, Koyuncu E, Tuncman G, Burak M, Merkel L, Bahour N, et al.
EMBO Mol Med
. 2025 Jan;
17(3):414-440.
PMID: 39843629
Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections,...
3.
Burak M, Tuncman G, Ayci A, Chetal K, Seropian G, Inouye K, et al.
bioRxiv
. 2024 Jul;
PMID: 39071372
One Sentence Summary: Investigating FABP4's pivotal role in obesity-driven airway disease, this study unveils an adipo-pulmonary axis with potential therapeutic implications.
4.
Tsaousidou E, Chrzanowski J, Drane P, Lee G, Bahour N, Wang Z, et al.
Cell Rep
. 2024 Jun;
43(6):114337.
PMID: 38861384
It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and...
5.
Parlakgul G, Pang S, Artico L, Min N, Cagampan E, Villa R, et al.
Nat Commun
. 2024 May;
15(1):3982.
PMID: 38729945
The hepatocytes within the liver present an immense capacity to adapt to changes in nutrient availability. Here, by using high resolution volume electron microscopy, we map how hepatic subcellular spatial...
6.
Qian Q, Li M, Zhang Z, Davis S, Rahmouni K, Norris A, et al.
Cell Metab
. 2024 May;
36(7):1550-1565.e9.
PMID: 38718793
Obesity alters levels of pituitary hormones that govern hepatic immune-metabolic homeostasis, dysregulation of which leads to nonalcoholic fatty liver disease (NAFLD). However, the impact of obesity on intra-pituitary homeostasis is...
7.
Burak M, Stanley T, Lawson E, Campbell S, Lynch L, Hasty A, et al.
Am J Clin Nutr
. 2024 May;
120(1):257-268.
PMID: 38705359
The rapidly evolving field of immunometabolism explores how changes in local immune environments may affect key metabolic and cellular processes, including that of adipose tissue. Importantly, these changes may contribute...
8.
Yuan B, Doxsey W, Tok O, Kwon Y, Inouye K, Hotamisligil G, et al.
bioRxiv
. 2024 Feb;
PMID: 38405872
Highlights: A flux model of energy metabolism integrating C labeling of metabolites and CO Circulating nutrients have characteristic partition between oxidation and storageCirculating nutrients' total cycling flux outweighs their total...
9.
Hirosumi J, Tuncman G, Chang L, Gorgun C, Uysal K, Maeda K, et al.
Nature
. 2023 Jun;
619(7968):E25.
PMID: 37328696
No abstract available.
10.
Inouye K, Prentice K, Lee A, Wang Z, Dominguez-Gonzalez C, Chen M, et al.
JCI Insight
. 2023 Jun;
8(14).
PMID: 37279064
Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon stimulation of lipolysis. Circulating FABP4 levels strongly correlate with obesity and metabolic pathologies in experimental models...