Manjula Pandey
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Explore the profile of Manjula Pandey including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
574
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Recent Articles
1.
Reed B, Meyer M, Abramzon V, Ad O, Adcock P, Ahmad F, et al.
Science
. 2022 Oct;
378(6616):186-192.
PMID: 36227977
Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity. Here, we demonstrate single-molecule protein sequencing using...
2.
Singh A, Pandey M, Nandakumar D, Raney K, Yin Y, Patel S
EMBO J
. 2020 Feb;
39(6):e103367.
PMID: 32037587
The proofreading exonuclease activity of replicative DNA polymerase excises misincorporated nucleotides during DNA synthesis, but these events are rare. Therefore, we were surprised to find that T7 replisome excised nearly...
3.
Chang H, Pandey M, Kulaeva O, Patel S, Studitsky V
Sci Adv
. 2016 Nov;
2(11):e1601865.
PMID: 27847876
Efficient overcoming and accurate maintenance of chromatin structure and associated histone marks during DNA replication are essential for normal functioning of the daughter cells. However, the molecular mechanisms of replication...
4.
Sun B, Pandey M, Inman J, Yang Y, Kashlev M, Patel S, et al.
Nat Commun
. 2015 Dec;
6:10260.
PMID: 26675048
Cells and viruses possess several known 'restart' pathways to overcome lesions during DNA replication. However, these 'bypass' pathways leave a gap in replicated DNA or require recruitment of accessory proteins,...
5.
Pandey M, Elshenawy M, Jergic S, Takahashi M, Dixon N, Hamdan S, et al.
Nucleic Acids Res
. 2015 May;
43(12):5924-35.
PMID: 26007657
The Escherichia coli replication terminator protein (Tus) binds to Ter sequences to block replication forks approaching from one direction. Here, we used single molecule and transient state kinetics to study...
6.
Nandakumar D, Pandey M, Patel S
Elife
. 2015 May;
4.
PMID: 25970034
Leading strand DNA synthesis requires functional coupling between replicative helicase and DNA polymerase (DNAP) enzymes, but the structural and mechanistic basis of coupling is poorly understood. This study defines the...
7.
Liao Z, Kato H, Pandey M, Cantor J, Ablooglu A, Ginsberg M, et al.
Blood
. 2015 Jan;
125(12):1995-2004.
PMID: 25587038
The bidirectional signaling and hemostatic functions of platelet αIIbβ3 are regulated by kindlin-3 through interactions with the β3 cytoplasmic tail. Little is known about kindlin regulation of the related "vitronectin...
8.
Pandey M, Patel S
Cell Rep
. 2014 Mar;
6(6):1129-1138.
PMID: 24630996
By simultaneously measuring DNA synthesis and dNTP hydrolysis, we show that T7 DNA polymerase and T7 gp4 helicase move in sync during leading-strand synthesis, taking one-nucleotide steps and hydrolyzing one...
9.
Syed S, Pandey M, Patel S, Ha T
Cell Rep
. 2014 Mar;
6(6):1037-1045.
PMID: 24630993
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxythymidine triphosphate (dTTP) hydrolysis to directional movement and DNA strand separation. We employed single-molecule fluorescence resonance energy...
10.
Ramanagoudr-Bhojappa R, Chib S, Byrd A, Aarattuthodiyil S, Pandey M, Patel S, et al.
J Biol Chem
. 2013 Apr;
288(22):16185-95.
PMID: 23596008
Kinetic analysis of the DNA unwinding and translocation activities of helicases is necessary for characterization of the biochemical mechanism(s) for this class of enzymes. Saccharomyces cerevisiae Pif1 helicase was characterized...