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Corina Hutterer

Explore the profile of Corina Hutterer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 416
Followers 0
Related Specialties
Microbiology
Chemistry
Biochemistry
Top 10 Co-Authors
Manfred Marschall
Sabrina Wagner
Jens Milbradt
Thomas Stamminger
Isabel Zeittrager
Hanife Bahsi
Svetlana B Tsogoeva
Mirjam Steingruber
Tony Frohlich
Oliver Friedrich
Published In
Antiviral Res
Viruses
J Gen Virol
Mol Cell Proteomics
Nat Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-herpesviruses provides a signature of virus-specific signalling
Marschall M, Strojan H, Kiener R, Wangen C, Sonntag E, Muller R, et al.
J Gen Virol . 2020 Jan; 101(3):284-289. PMID: 31958050
Infections with human herpesviruses share several molecular characteristics, but the diversified medical outcomes are distinct to viral subfamilies and species. Notably, both clinical and molecular correlates of infection are a...
2.
Chemically sulfated polysaccharides from natural sources: Assessment of extraction-sulfation efficiencies, structural features and antiviral activities
Mukherjee S, Ghosh K, Hahn F, Wangen C, Strojan H, Muller R, et al.
Int J Biol Macromol . 2019 Jun; 136:521-530. PMID: 31158418
The provisioning of compound libraries with a high degree of diversity and attractive pharmacological properties is a limiting step in drug development. This study reports the production of highly bioactive...
3.
Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication
Hamilton S, Hutterer C, Egilmezer E, Steingruber M, Milbradt J, Marschall M, et al.
Placenta . 2018 Dec; 72-73:10-19. PMID: 30501876
Introduction: Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation and in severe cases fetal and neonatal death. Fetal injury may be caused indirectly by the placental response to infection....
4.
Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity
Hahn F, Hutterer C, Henry C, Hamilton S, Strojan H, Kraut A, et al.
Antiviral Res . 2018 Oct; 159:84-94. PMID: 30268914
Human cytomegalovirus (HCMV) is a major human pathogen with seropositivity rates in the adult population ranging between 40% and 95%. HCMV infection is associated with severe pathology, such as life-threatening...
5.
Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against , Human Cytomegalovirus, and Leukemia Cells
Frohlich T, Reiter C, Ibrahim M, Beutel J, Hutterer C, Zeittrager I, et al.
ACS Omega . 2018 Jul; 2(6):2422-2431. PMID: 30023664
Many quinazoline derivatives have been synthesized over the last few decades with great pharmacological potential, such as antimalarial, anti-inflammatory, antimicrobial, anticancer, and antiviral. But so far, no quinazoline-artemisinin hybrids have...
6.
Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents
Frohlich T, Reiter C, Saeed M, Hutterer C, Hahn F, Leidenberger M, et al.
ACS Med Chem Lett . 2018 Jun; 9(6):534-539. PMID: 29937978
A series of hybrid compounds based on the natural products artemisinin and thymoquinone was synthesized and investigated for their biological activity against the malaria parasite 3D7 strain, human cytomegalovirus (HCMV),...
7.
Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products
Bock C, Parameshwarappa G, Bonisch S, Bauer W, Hutterer C, Leidenberger M, et al.
ChemistryOpen . 2017 Jun; 6(3):364-374. PMID: 28638769
The straightforward and efficient synthesis of complex aza- and carbobicyclic compounds, which are of importance for medicinal chemistry, is a challenge for modern chemical methodology. An unprecedented metal-free six-step domino...
8.
Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
Held F, Guryev A, Frohlich T, Hampel F, Kahnt A, Hutterer C, et al.
Nat Commun . 2017 May; 8:15071. PMID: 28462939
Most of the known approved drugs comprise functionalized heterocyclic compounds as subunits. Among them, non-fluorescent quinazolines with four different substitution patterns are found in a variety of clinically used pharmaceuticals,...
9.
Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity
Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, et al.
Antiviral Res . 2017 Apr; 143:113-121. PMID: 28400201
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of (val)ganciclovir therapy is hampered by low drug compatibility and induction of...
10.
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress
Milbradt J, Hutterer C, Bahsi H, Wagner S, Sonntag E, Horn A, et al.
PLoS Pathog . 2016 Aug; 12(8):e1005825. PMID: 27556400
The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein...