Sigrun Hage
Overview
Explore the profile of Sigrun Hage including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
201
Followers
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Recent Articles
1.
Gege C, Hahn F, Wangen C, Hage S, Herrmann A, Uhlig N, et al.
ChemMedChem
. 2024 Jun;
19(19):e202400292.
PMID: 38887198
New strategies for the rapid development of broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Host-directed antivirals that...
2.
Tillmanns J, Hage S, Borst E, Wardin J, Eickhoff J, Klebl B, et al.
Cells
. 2023 May;
12(8).
PMID: 37190072
Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a...
3.
Kicuntod J, Hage S, Losing J, Kopar S, Muller Y, Marschall M
Antiviral Res
. 2023 Feb;
212:105557.
PMID: 36796541
The nucleocytoplasmic capsid egress of herpesviruses like the human cytomegalovirus (HCMV) is based on a uniquely regulated process. The core nuclear egress complex (NEC) of HCMV, represented by the pUL50-pUL53...
4.
Hahn F, Wangen C, Hage S, Herrmann L, Herrmann A, Tsogoeva S, et al.
Pharmaceutics
. 2023 Jan;
15(1).
PMID: 36678744
Starting in 2019, the spread of respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated pandemic of the corona virus disease (COVID-19) has led to enormous efforts in the development of...
5.
Losing J, Hage S, Schutz M, Wagner S, Wardin J, Sticht H, et al.
Cells
. 2022 Dec;
11(24).
PMID: 36552794
Herpesviruses replicate their genomes and assemble their capsids in the host cell nucleus. To progress towards morphogenesis in the cytoplasm, herpesviruses evolved the strategy of nuclear egress as a highly...
6.
Hage S, Marschall M
Cells
. 2022 Jun;
11(11).
PMID: 35681532
Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of...
7.
Kicuntod J, Hage S, Hahn F, Sticht H, Marschall M
Viruses
. 2022 May;
14(5).
PMID: 35632762
The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress...
8.
Schweininger J, Kriegel M, Hage S, Conrad M, Alkhashrom S, Losing J, et al.
J Biol Chem
. 2022 Jan;
298(3):101625.
PMID: 35074430
Varicella-zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. The VZV Orf24-Orf27 complex represents the essential viral core nuclear egress complex (NEC) that orchestrates the egress of...
9.
Hage S, Buscher N, Pakulska V, Hahn F, Adrait A, Krauter S, et al.
Cells
. 2021 Nov;
10(11).
PMID: 34831342
The regulation of the nucleocytoplasmic release of herpesviral capsids is defined by the process of nuclear egress. Due to their large size, nuclear capsids are unable to traverse via nuclear...
10.
Hahn F, Hage S, Herrmann A, Wangen C, Kicuntod J, Jungnickl D, et al.
Pathogens
. 2021 Sep;
10(9).
PMID: 34578109
Currently, human infections with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are accelerating the ongoing spread of the pandemic. Several innovative types of vaccines have already been developed,...