Mamatha Seethammagari
Overview
Explore the profile of Mamatha Seethammagari including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
191
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0
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Recent Articles
1.
Kemnade J, Seethammagari M, Collinson-Pautz M, Kaur H, Spencer D, McCormick A
Vaccine
. 2014 Jun;
32(33):4228-33.
PMID: 24923637
Over the past 20 years, dendritic cells (DCs) have been utilized to activate immune responses capable of eliminating cancer cells. Currently, ex vivo DC priming has been the mainstay of...
2.
Carstens J, Shahi P, Van Tsang S, Smith B, Creighton C, Zhang Y, et al.
Cancer Res
. 2013 Dec;
74(2):609-20.
PMID: 24305876
The reactive stroma surrounding tumor lesions performs critical roles ranging from supporting tumor cell proliferation to inducing tumorigenesis and metastasis. Therefore, it is critical to understand the cellular components and...
3.
Kemnade J, Seethammagari M, Narayanan P, Levitt J, McCormick A, Spencer D
Mol Ther
. 2012 Mar;
20(7):1462-71.
PMID: 22434138
Recent modest successes in ex vivo dendritic cell (DC) immunotherapy have motivated continued innovation in the area of DC manipulation and activation. Although ex vivo vaccine approaches continue to be...
4.
Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis
Shahi P, Park D, Pond A, Seethammagari M, Chiou S, Cho K, et al.
PLoS One
. 2012 Feb;
7(1):e30814.
PMID: 22303459
Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo...
5.
Chiou S, Shahi P, Wagner R, Hu H, Lapteva N, Seethammagari M, et al.
EMBO Rep
. 2011 Jul;
12(9):971-9.
PMID: 21799517
The activation of innate and adaptive immunity is always balanced by inhibitory signalling mechanisms to maintain tissue integrity. We have identified the E3 ligase c-Cbl--known for its roles in regulating...
6.
Narayanan P, Lapteva N, Seethammagari M, Levitt J, Slawin K, Spencer D
J Clin Invest
. 2011 Mar;
121(4):1524-34.
PMID: 21383499
The in vivo therapeutic efficacy of DC-based cancer vaccines is limited by suboptimal DC maturation protocols. Although delivery of TLR adjuvants systemically boosts DC-based cancer vaccine efficacy, it could also...
7.
Ramachandran I, Song W, Lapteva N, Seethammagari M, Slawin K, Spencer D, et al.
J Immunol
. 2011 Mar;
186(7):3934-45.
PMID: 21357539
Dendritic cells (DCs) initiate proinflammatory or regulatory T cell responses, depending on their activation state. Despite extensive knowledge of DC-activating signals, the understanding of DC inhibitory signals is relatively limited....
8.
Park D, Lapteva N, Seethammagari M, Slawin K, Spencer D
Nat Biotechnol
. 2006 Dec;
24(12):1581-90.
PMID: 17143278
Current dendritic cell (DC) vaccine preparations involving ex vivo differentiation and maturation produce short-lived, transiently active DCs that may curtail T-cell responses in vivo. We demonstrate that Akt1, downregulation of...