Mahesh Darna
Overview
Explore the profile of Mahesh Darna including associated specialties, affiliations and a list of published articles.
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16
Citations
272
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Recent Articles
1.
Taur J, Zhao C, Darna M, Chang Y, Lu Y, Mao J, et al.
AAPS J
. 2023 Mar;
25(2):28.
PMID: 36859483
The bioanalysis of drugs that undergo acyl glucuronidation presents an analytical challenge due to poor stability of acyl glucuronide metabolites in biological matrices. The objective of this study was to...
2.
Richter K, Schmutz I, Darna M, Zander J, Chavan R, Albrecht U, et al.
Neuroscience
. 2017 Dec;
371:29-37.
PMID: 29199069
Glutamate is concentrated into synaptic vesicles (SV) by the vesicular glutamate transporters (VGLUT) 1 and 2. VGLUTs also harbor a Na+/Pi-transport activity when residing at the plasma membrane. Here we...
3.
Marusich J, Darna M, George Wilson A, Denehy E, Ebben A, Deaciuc A, et al.
Eur J Pharmacol
. 2017 Aug;
814:196-206.
PMID: 28844873
Tobacco products are some of the most commonly used psychoactive drugs worldwide. Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific investigation of these constituents and their contribution...
4.
Chow J, Nickell J, Darna M, Beckmann J
Neuropharmacology
. 2016 Jul;
109:320-331.
PMID: 27371135
Stimulus-reward learning has been heavily linked to the reward-prediction error learning hypothesis and dopaminergic function. However, some evidence suggests dopaminergic function may not strictly underlie reward-prediction error learning, but may...
5.
Lee N, Zhang X, Darna M, Dwoskin L, Zheng G
Bioorg Med Chem Lett
. 2015 Oct;
25(22):5032-5.
PMID: 26494260
A series of pethidine analogs were synthesized and their affinities for the [(3)H]N-methyl-scopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M1, M3 or M5 human mAChRs...
6.
Darna M, Chow J, Yates J, Charnigo R, Beckmann J, Bardo M, et al.
Behav Brain Res
. 2015 Jul;
293:134-42.
PMID: 26183652
Impulsivity is a multi-faceted personality construct that plays a prominent role in drug abuse vulnerability. Dysregulation of 5-hydroxytryptamine (serotonin, 5-HT) systems in subregions of the prefrontal cortex has been implicated...
7.
Yates J, Darna M, Gipson C, Dwoskin L, Bardo M
Behav Brain Res
. 2015 May;
291:201-208.
PMID: 26005123
Negative urgency is a facet of impulsivity that reflects mood-based rash action and is associated with various maladaptive behaviors in humans. However, the underlying neural mechanisms of negative urgency are...
8.
Darna M, Beckmann J, Gipson C, Bardo M, Dwoskin L
Brain Res
. 2014 Dec;
1599:115-25.
PMID: 25536304
Recent studies have reported that rats raised in an enriched condition (EC) have decreased dopamine transporter (DAT) function and expression in medial prefrontal cortex (mPFC), as well as increased d-amphetamine-induced...
9.
Hofford R, Darna M, Wilmouth C, Dwoskin L, Bardo M
Behav Brain Res
. 2014 May;
270:151-8.
PMID: 24821405
Environmental factors influence a variety of health-related outcomes. In general, being raised in an environment possessing social, sensory, and motor enrichment reduces the rewarding effects of various drugs, thus protecting...
10.
Somkuwar S, Darna M, Kantak K, Dwoskin L
Biochem Pharmacol
. 2013 Apr;
86(2):309-16.
PMID: 23623751
Attention deficit/hyperactivity disorder (ADHD) is attributed to dysfunction of the prefrontal cortex. Methylphenidate, an inhibitor of dopamine and norepinephrine transporters (DAT and NET, respectively), is a standard treatment for ADHD....