Muscarinic Acetylcholine Receptor Binding Affinities of Pethidine Analogs

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2015 Oct 24

PMID 26494260

Citations 1

Authors

Na-Ra Lee

Xuan Zhang

Mahesh Darna

Linda P Dwoskin

Guangrong Zheng

Affiliations

Soon will be listed here.

Abstract

A series of pethidine analogs were synthesized and their affinities for the [(3)H]N-methyl-scopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M1, M3 or M5 human mAChRs expressed by Chinese hamster ovary (CHO) cell membranes. Compound 6b showed the highest binding affinities at M1, M3 and M5 mAChRs (Ki=0.67, 0.37, and 0.38 μM, respectively).

Citing Articles

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Lee N, Gujarathi S, Bommagani S, Siripurapu K, Zheng G, Dwoskin L Bioorg Med Chem Lett. 2018; 29(3):471-476.

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