Maarten Jacquemyn
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Explore the profile of Maarten Jacquemyn including associated specialties, affiliations and a list of published articles.
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21
Citations
516
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Recent Articles
11.
Guo W, Wang H, Tharkeshwar A, Couthouis J, Braems E, Masrori P, et al.
Alzheimers Dement
. 2022 Aug;
19(4):1245-1259.
PMID: 35993441
Introduction: The most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are hexanucleotide repeats in chromosome 9 open reading frame 72 (C9orf72). These repeats produce dipeptide...
12.
Baggen J, Persoons L, Vanstreels E, Jansen S, Van Looveren D, Boeckx B, et al.
Nat Genet
. 2021 Mar;
53(4):435-444.
PMID: 33686287
The ongoing COVID-19 pandemic has caused a global economic and health crisis. To identify host factors essential for coronavirus infection, we performed genome-wide functional genetic screens with severe acute respiratory...
13.
Boons E, Nogueira T, Dierckx T, Menezes S, Jacquemyn M, Tamir S, et al.
Blood Cancer J
. 2021 Feb;
11(2):27.
PMID: 33563902
No abstract available.
14.
Rosu A, El Hachem N, Rapino F, Rouault-Pierre K, Jorssen J, Somja J, et al.
J Exp Med
. 2021 Jan;
218(3).
PMID: 33507234
The hematopoietic system is highly sensitive to perturbations in the translational machinery, of which an emerging level of regulation lies in the epitranscriptomic modification of transfer RNAs (tRNAs). Here, we...
15.
Neggers J, Jacquemyn M, Dierckx T, Kleinstiver B, Thibaut H, Daelemans D
Mol Ther
. 2020 Oct;
29(1):208-224.
PMID: 33002419
While drug resistance mutations provide the gold standard proof for drug target engagement, target deconvolution of inhibitors identified from a phenotypic screen remains challenging. Genetic screening for functional in-frame drug...
16.
Tazelaar G, Boeynaems S, De Decker M, van Vugt J, Kool L, Goedee H, et al.
Brain Commun
. 2020 Sep;
2(2):fcaa064.
PMID: 32954321
Increasingly, repeat expansions are being identified as part of the complex genetic architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been genetically associated with the disease: intronic...
17.
Martin A, Jacquemyn M, Lipecka J, Chhuon C, Aushev V, Meunier B, et al.
EMBO Rep
. 2019 Sep;
20(11):e48150.
PMID: 31544310
STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250...
18.
Saenz-Ponce N, Pillay R, de Long L, Kashyap T, Argueta C, Landesman Y, et al.
Sci Transl Med
. 2018 Jun;
10(447).
PMID: 29950445
Patient mortality rates have remained stubbornly high (40%) for the past 35 years in head and neck squamous cell carcinoma (HNSCC) due to inherent or acquired drug resistance. Thus, a...
19.
Neggers J, Kwanten B, Dierckx T, Noguchi H, Voet A, Bral L, et al.
Nat Commun
. 2018 Feb;
9(1):502.
PMID: 29402884
Unraveling the mechanism of action and molecular target of small molecules remains a major challenge in drug discovery. While many cancer drugs target genetic vulnerabilities, loss-of-function screens fail to identify...
20.
Vercruysse T, De Bie J, Neggers J, Jacquemyn M, Vanstreels E, Schmid-Burgk J, et al.
Clin Cancer Res
. 2016 Nov;
23(10):2528-2541.
PMID: 27780859
Human exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports different cargo proteins out of the nucleus. Inducing nuclear accumulation of these proteins by inhibiting XPO1 causes cancer cell...