M F Hirshman
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Explore the profile of M F Hirshman including associated specialties, affiliations and a list of published articles.
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50
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4265
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Recent Articles
1.
Middelbeek R, Chambers M, Tantiwong P, Treebak J, An D, Hirshman M, et al.
Nutr Diabetes
. 2013 Jun;
3:e74.
PMID: 23752133
Introduction: Individuals with obesity and type 2 diabetes (T2D) are typically insulin resistant, exhibiting impaired skeletal muscle glucose uptake. Animal and cell culture experiments have shown that site-specific phosphorylation of...
2.
Witczak C, Hirshman M, Jessen N, Fujii N, Seifert M, Brandauer J, et al.
Biochem Biophys Res Commun
. 2006 Oct;
350(4):1063-8.
PMID: 17045576
Mice deficient in c-jun-NH(2)-terminal kinase 1 (JNK1) exhibit decreased fasting blood glucose and insulin levels, and protection against obesity-induced insulin resistance, suggesting increased glucose disposal into skeletal muscle. Thus, we...
3.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al.
J Clin Invest
. 2001 Oct;
108(8):1167-74.
PMID: 11602624
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased...
4.
Tian R, Musi N, DAgostino J, Hirshman M, Goodyear L
Circulation
. 2001 Oct;
104(14):1664-9.
PMID: 11581146
Background: Recent reports suggest that activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), in response to acute changes in cellular energy status in cardiac and skeletal muscles, results in altered...
5.
Aschenbach W, Suzuki Y, Breeden K, Prats C, Hirshman M, Dufresne S, et al.
J Biol Chem
. 2001 Aug;
276(43):39959-67.
PMID: 11522787
In skeletal muscle both insulin and contractile activity are physiological stimuli for glycogen synthesis, which is thought to result in part from the dephosphorylation and activation of glycogen synthase (GS)....
6.
Musi N, Fujii N, Hirshman M, Ekberg I, Froberg S, Ljungqvist O, et al.
Diabetes
. 2001 May;
50(5):921-7.
PMID: 11334434
Insulin-stimulated GLUT4 translocation is impaired in people with type 2 diabetes. In contrast, exercise results in a normal increase in GLUT4 translocation and glucose uptake in these patients. Several groups...
7.
Musi N, Hayashi T, Fujii N, Hirshman M, Witters L, Goodyear L
Am J Physiol Endocrinol Metab
. 2001 Apr;
280(5):E677-84.
PMID: 11287349
The AMP-activated protein kinase (AMPK) has been hypothesized to mediate contraction and 5-aminoimidazole-4-carboxamide 1-beta-D-ribonucleoside (AICAR)-induced increases in glucose uptake in skeletal muscle. The purpose of the current study was to...
8.
Higaki Y, Hirshman M, Fujii N, Goodyear L
Diabetes
. 2001 Mar;
50(2):241-7.
PMID: 11272132
Insulin, contraction, and the nitric oxide (NO) donor, sodium nitroprusside (SNP), all increase glucose transport in skeletal muscle. Some reports suggest that NO is a critical mediator of insulin- and/or...
9.
Boppart M, Hirshman M, Sakamoto K, Fielding R, Goodyear L
Am J Physiol Cell Physiol
. 2001 Feb;
280(2):C352-8.
PMID: 11208531
Physical exercise and contraction increase c-Jun NH2-terminal kinase (JNK) activity in rat and human skeletal muscle, and eccentric contractions activate JNK to a greater extent than concentric contractions in human...
10.
Zisman A, Peroni O, Abel E, Michael M, Mauvais-Jarvis F, Lowell B, et al.
Nat Med
. 2000 Aug;
6(8):924-8.
PMID: 10932232
The prevalence of type 2 diabetes mellitus is growing worldwide. By the year 2020, 250 million people will be afflicted. Most forms of type 2 diabetes are polygenic with complex...