M F Hirshman
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Explore the profile of M F Hirshman including associated specialties, affiliations and a list of published articles.
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4265
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Recent Articles
11.
Fujii N, Hayashi T, Hirshman M, Smith J, Habinowski S, Kaijser L, et al.
Biochem Biophys Res Commun
. 2000 Jul;
273(3):1150-5.
PMID: 10891387
The 5'AMP-activated protein kinase (AMPK) is stimulated by contractile activity in rat skeletal muscle. AMPK has emerged as an important signaling intermediary in the regulation of cell metabolism being linked...
12.
Hayashi T, Hirshman M, Fujii N, Habinowski S, Witters L, Goodyear L
Diabetes
. 2000 Jun;
49(4):527-31.
PMID: 10871188
5'AMP-activated protein kinase (AMPK) can be activated in response to cellular fuel depletion and leads to switching off ATP-consuming pathways and switching on ATP-regenerating pathways in many cell types. We...
13.
Wojtaszewski J, Higaki Y, Hirshman M, Michael M, Dufresne S, Kahn C, et al.
J Clin Invest
. 1999 Nov;
104(9):1257-64.
PMID: 10545524
Physical exercise promotes glucose uptake into skeletal muscle and makes the working muscles more sensitive to insulin. To understand the role of insulin receptor (IR) signaling in these responses, we...
14.
Thorell A, Hirshman M, Nygren J, Jorfeldt L, Wojtaszewski J, Dufresne S, et al.
Am J Physiol
. 1999 Oct;
277(4):E733-41.
PMID: 10516134
Studies in rodents have established that GLUT-4 translocation is the major mechanism by which insulin and exercise increase glucose uptake in skeletal muscle. In contrast, much less is known about...
15.
Hayashi T, Hirshman M, Dufresne S, Goodyear L
Am J Physiol
. 1999 Oct;
277(4):C701-7.
PMID: 10516100
Physical exercise is a potent stimulator of mitogen-activated protein (MAP) kinase signaling. To determine if this activation is secondary to systemic responses to exercise or due to muscle contractile activity...
16.
Hirshman M, Goodyear L, Winder W
Diabetes
. 1999 Jul;
48(8):1667-71.
PMID: 10426389
It has previously been reported that exercise causes an increase in glucose uptake in skeletal muscle and also an increase in 5' AMP-activated protein kinase (AMPK) activity. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA-riboside), an...
17.
Higaki Y, Wojtaszewski J, Hirshman M, Withers D, Towery H, White M, et al.
J Biol Chem
. 1999 Jul;
274(30):20791-5.
PMID: 10409618
Insulin receptor substrate-2-deficient (IRS2(-/-)) mice develop type 2 diabetes. The purpose of this study was to determine whether there is a defect in basal, insulin-, and exercise-stimulated glucose transport in...
18.
Kennedy J, Hirshman M, Gervino E, Ocel J, Forse R, Hoenig S, et al.
Diabetes
. 1999 May;
48(5):1192-7.
PMID: 10331428
Total GLUT4 content in skeletal muscle from individuals with type 2 diabetes is normal; however, recent studies have demonstrated that translocation of GLUT4 to the plasma membrane is decreased in...
19.
Thorell A, Nygren J, Hirshman M, Hayashi T, Nair K, Horton E, et al.
Am J Physiol
. 1999 Apr;
276(4):E754-61.
PMID: 10198313
To investigate the underlying molecular mechanisms for surgery-induced insulin resistance in skeletal muscle, six otherwise healthy patients undergoing total hip replacement were studied before, during, and after surgery. Patients were...
20.
Giorgino F, Logoluso F, Davalli A, Napoli R, Laviola L, Hirshman M, et al.
Diabetes
. 1999 Apr;
48(4):801-12.
PMID: 10102697
Insulin-dependent diabetes in rats is characterized by abnormalities of post-binding insulin signaling reactions that are not fully corrected by exogenous insulin therapy. The aim of this study was to investigate...