Jamie A Hackett
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Explore the profile of Jamie A Hackett including associated specialties, affiliations and a list of published articles.
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30
Citations
2086
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Recent Articles
1.
Policarpi C, Munafo M, Tsagkris S, Carlini V, Hackett J
Nat Genet
. 2024 May;
56(6):1168-1180.
PMID: 38724747
Chromatin modifications are linked with regulating patterns of gene expression, but their causal role and context-dependent impact on transcription remains unresolved. Here we develop a modular epigenome editing platform that...
2.
Argaw-Denboba A, Schmidt T, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, et al.
Nature
. 2024 May;
629(8012):652-659.
PMID: 38693261
The gut microbiota operates at the interface of host-environment interactions to influence human homoeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore shape physiological and disease-associated...
3.
Carbognin E, Carlini V, Panariello F, Chieregato M, Guerzoni E, Benvegnu D, et al.
Nat Cell Biol
. 2023 Apr;
25(5):643-657.
PMID: 37106060
During embryonic development, naive pluripotent epiblast cells transit to a formative state. The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and epigenetic profiles and acquire competence to...
4.
Carlini V, Policarpi C, Hackett J
EMBO J
. 2022 Feb;
41(7):e108677.
PMID: 35199868
Environmental factors can trigger cellular responses that propagate across mitosis or even generations. Perturbations to the epigenome could underpin such acquired changes, however, the extent and contexts in which modified...
5.
Policarpi C, Dabin J, Hackett J
Bioessays
. 2021 Mar;
43(5):e2000316.
PMID: 33724509
How epigenetic mechanisms regulate genome output and response to stimuli is a fundamental question in development and disease. Past decades have made tremendous progress in deciphering the regulatory relationships involved...
6.
Bergert M, Lembo S, Sharma S, Russo L, Milovanovic D, Gretarsson K, et al.
Cell Stem Cell
. 2020 Nov;
28(2):209-216.e4.
PMID: 33207217
Cell differentiation typically occurs with concomitant shape transitions to enable specialized functions. To adopt a different shape, cells need to change the mechanical properties of their surface. However, whether cell...
7.
Carlini V, Gretarsson K, Hackett J
Methods Mol Biol
. 2020 Sep;
2214:91-108.
PMID: 32944905
Knockout CRISPR screening enables the unbiased discovery of genes with a functional role in almost any cellular or molecular process of interest. The approach couples a genome-scale library of guide...
8.
Gretarsson K, Hackett J
Nat Struct Mol Biol
. 2020 Jun;
27(8):706-716.
PMID: 32572256
Early mammalian development entails genome-wide epigenome remodeling, including DNA methylation erasure and reacquisition, which facilitates developmental competence. To uncover the mechanisms that orchestrate DNA methylation dynamics, we coupled a single-cell...
9.
Maffei M, Morelli C, Graham E, Patriarca S, Donzelli L, Doleschall B, et al.
Sci Rep
. 2019 Dec;
9(1):19214.
PMID: 31844114
Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells....
10.
Hackett J, Huang Y, Gunesdogan U, Gretarsson K, Kobayashi T, Surani M
Nat Commun
. 2018 Dec;
9(1):5328.
PMID: 30538240
Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated...