M Azim Surani
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Explore the profile of M Azim Surani including associated specialties, affiliations and a list of published articles.
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149
Citations
13111
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Recent Articles
11.
Gruhn W, Tang W, Dietmann S, Alves-Lopes J, Penfold C, Wong F, et al.
Sci Adv
. 2023 Jan;
9(3):eade1257.
PMID: 36652508
Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ...
12.
Alves-Lopes J, Wong F, Tang W, Gruhn W, Ramakrishna N, Jowett G, et al.
Cell Rep
. 2023 Jan;
42(1):111907.
PMID: 36640324
Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified during weeks 2-3 after fertilization. Few studies on ex vivo and in vitro cultured human embryos reported...
13.
Floros V, Pyle A, Dietmann S, Wei W, Tang W, Irie N, et al.
Nat Cell Biol
. 2022 Dec;
25(1):194.
PMID: 36522542
No abstract available.
14.
Ramakrishna N, Battistoni G, Surani M, Hannon G, Miska E
Dev Cell
. 2022 Dec;
57(23):2661-2668.e5.
PMID: 36473462
PIWI-interacting RNAs (piRNAs) are small RNAs bound by PIWI-clade Argonaute proteins that function to silence transposable elements (TEs). Following mouse primordial germ cell (mPGC) specification around E6.25, fetal piRNAs emerge...
15.
Tang W, Castillo-Venzor A, Gruhn W, Kobayashi T, Penfold C, Morgan M, et al.
Nat Cell Biol
. 2022 Apr;
24(4):448-460.
PMID: 35411086
Germline-soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell...
16.
Kobayashi T, Castillo-Venzor A, Penfold C, Morgan M, Mizuno N, Tang W, et al.
Cell Rep
. 2021 Oct;
37(2):109812.
PMID: 34644585
Rabbit embryos develop as bilaminar discs at gastrulation as in humans and most other mammals, whereas rodents develop as egg cylinders. Primordial germ cells (PGCs) appear to originate during gastrulation...
17.
Alberio R, Kobayashi T, Surani M
Stem Cell Reports
. 2021 May;
16(5):1078-1092.
PMID: 33979595
Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate...
18.
Kobayashi T, Goto T, Oikawa M, Sanbo M, Yoshida F, Terada R, et al.
Nat Commun
. 2021 Feb;
12(1):1328.
PMID: 33637711
Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the quality...
19.
Wu B, Li Y, Li B, Zhang B, Wang Y, Li L, et al.
Stem Cell Reports
. 2021 Feb;
16(3):582-596.
PMID: 33636115
Naive pluripotency can be maintained in medium with two inhibitors plus leukemia inhibitory factor (2i/LIF) supplementation, which primarily affects canonical WNT, FGF/ERK, and JAK/STAT3 signaling. However, whether one of these...
20.
Zhu Q, Sang F, Withey S, Tang W, Dietmann S, Klisch D, et al.
Cell Rep
. 2021 Feb;
34(6):108735.
PMID: 33567277
Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic...