Luke Whitesell
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Explore the profile of Luke Whitesell including associated specialties, affiliations and a list of published articles.
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99
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5267
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Recent Articles
1.
Puumala E, Nandakumar M, Yiu B, Stogios P, Strickland B, Zarnowski R, et al.
Nat Commun
. 2025 Mar;
16(1):2156.
PMID: 40038303
Candida albicans is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications...
2.
Cowen L, Puumala E, Nandakumar M, Yiu B, Stogios P, Strickland B, et al.
Res Sq
. 2025 Jan;
PMID: 39866870
is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications but remain...
3.
Shirley D, Nandakumar M, Cabrera A, Yiu B, Puumala E, Liu Z, et al.
bioRxiv
. 2025 Jan;
PMID: 39829896
is a growing health concern as the leading causal agent of systemic candidiasis, a life-threatening fungal infection with a mortality rate of ~40% despite best available therapy. Yck2, a fungal...
4.
Puumala E, Nabeela S, Thornburg C, Grkovic T, Uppuluri P, Whitesell L, et al.
Antimicrob Agents Chemother
. 2024 Sep;
68(11):e0119424.
PMID: 39324798
Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with...
5.
MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie N, Todd R, et al.
Nat Commun
. 2024 Aug;
15(1):6440.
PMID: 39090082
No abstract available.
6.
MacAlpine J, Daniel-Ivad M, Atere D, Laflamme B, Robbins N, Navarre W, et al.
Nat Commun
. 2024 Aug;
15(1):6441.
PMID: 39090077
No abstract available.
7.
Alasady M, Koeva M, Takagishi S, Segal D, Amici D, Smith R, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2313370121.
PMID: 38985769
Heat Shock Factor 1 (HSF1) is best known as the master transcriptional regulator of the heat-shock response (HSR), a conserved adaptive mechanism critical for protein homeostasis (proteostasis). Combining a genome-wide...
8.
Puumala E, Sychantha D, Lach E, Reeves S, Nabeela S, Fogal M, et al.
Cell Chem Biol
. 2024 Feb;
31(4):760-775.e17.
PMID: 38402621
Candida species are among the most prevalent causes of systemic fungal infections, which account for ∼1.5 million annual fatalities. Here, we build on a compound screen that identified the molecule...
9.
Fallah S, Duncan D, Reichl K, Smith M, Wang W, Porco Jr J, et al.
Microbiol Spectr
. 2024 Feb;
12(4):e0409523.
PMID: 38376363
, one of the most prevalent human fungal pathogens, causes diverse diseases extending from superficial infections to deadly systemic mycoses. Currently, only three major classes of antifungal drugs are available...
10.
Case N, Westman J, Hallett M, Plumb J, Farheen A, Maxson M, et al.
mBio
. 2023 Dec;
14(6):e0274523.
PMID: 38038475
is a leading human fungal pathogen that often causes life-threatening infections in immunocompromised individuals. The ability of to transition between yeast and filamentous forms is key to its virulence, and...