Susan Lindquist
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Explore the profile of Susan Lindquist including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Lam I, Ndayisaba A, Lewis A, Fu Y, Sagredo G, Kuzkina A, et al.
Neuron
. 2025 Feb;
113(4):637.
PMID: 39894019
No abstract available.
2.
Lam I, Ndayisaba A, Lewis A, Fu Y, Sagredo G, Kuzkina A, et al.
Neuron
. 2024 Jul;
112(17):2886-2909.e16.
PMID: 39079530
The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is poorly understood. Standard patient-derived iPSC models develop inclusions neither reproducibly nor in a reasonable time frame. Here, we developed...
3.
Alasady M, Koeva M, Takagishi S, Segal D, Amici D, Smith R, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2313370121.
PMID: 38985769
Heat Shock Factor 1 (HSF1) is best known as the master transcriptional regulator of the heat-shock response (HSR), a conserved adaptive mechanism critical for protein homeostasis (proteostasis). Combining a genome-wide...
4.
Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, et al.
bioRxiv
. 2024 Mar;
PMID: 38496508
Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are...
5.
Hallacli E, Kayatekin C, Nazeen S, Wang X, Sheinkopf Z, Sathyakumar S, et al.
Cell
. 2022 Jun;
185(12):2035-2056.e33.
PMID: 35688132
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we show that αS directly modulates...
6.
Smith R, Takagishi S, Amici D, Metz K, Gayatri S, Alasady M, et al.
Sci Adv
. 2022 Mar;
8(11):eabj6526.
PMID: 35294249
Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and...
7.
Nishida Y, Zhao R, Heese L, Akiyama H, Patel S, Jaeger A, et al.
Leukemia
. 2021 Jun;
35(9):2469-2481.
PMID: 34127794
Eukaryotic initiation factor 4A (eIF4A), the enzymatic core of the eIF4F complex essential for translation initiation, plays a key role in the oncogenic reprogramming of protein synthesis, and thus is...
8.
Sienski G, Narayan P, Bonner J, Kory N, Boland S, Arczewska A, et al.
Sci Transl Med
. 2021 Mar;
13(583).
PMID: 33658354
The allele of the apolipoprotein E gene () has been established as a genetic risk factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD), yet its mechanism of...
9.
Narayan P, Sienski G, Bonner J, Lin Y, Seo J, Baru V, et al.
Cell Rep
. 2020 Oct;
33(1):108224.
PMID: 33027662
The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer's disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived...
10.
Tsvetkov P, Eisen T, Heinrich S, Brune Z, Hallacli E, Newby G, et al.
Cell Rep
. 2020 Sep;
32(10):108149.
PMID: 32905780
No abstract available.