Luke M McAloon
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Explore the profile of Luke M McAloon including associated specialties, affiliations and a list of published articles.
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5
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58
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Recent Articles
1.
Smiles W, Ovens A, Yu D, Ling N, Poblete Goycoolea A, Morrison K, et al.
NPJ Metab Health Dis
. 2025 Mar;
3(1):8.
PMID: 40052110
The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its...
2.
Horne C, Dite T, Young S, Mather L, Dagley L, Johnson J, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2420961122.
PMID: 39964718
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1...
3.
McAloon L, Muller A, Nay K, Lu E, Smeuninx B, Means A, et al.
Essays Biochem
. 2024 Sep;
68(3):309-320.
PMID: 39268917
Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different processes yet cause stimulus specific...
4.
Kaiser J, Nay K, Horne C, McAloon L, Fuller O, Muller A, et al.
Mol Psychiatry
. 2023 Sep;
28(11):4500-4511.
PMID: 37730845
Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of action. Advances in drug development for...
5.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, et al.
Cell Rep
. 2022 Dec;
41(12):111862.
PMID: 36543129
AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of glycine-2 (Gly2) of the AMPK β subunit has...
6.
Nay K, Smiles W, Kaiser J, McAloon L, Loh K, Galic S, et al.
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33919972
As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing...
7.
Langendorf C, OBrien M, Ngoei K, McAloon L, Dhagat U, Hoque A, et al.
J Biol Chem
. 2020 Sep;
295(48):16239-16250.
PMID: 32913128
The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism. It is known to be activated by increases in intracellular Ca, but the mechanisms...