Luke A Pattison
Overview
Explore the profile of Luke A Pattison including associated specialties, affiliations and a list of published articles.
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18
Citations
277
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Recent Articles
1.
Aguilera-Lizarraga J, Lim T, Pattison L, Paine L, Bulmer D, Smith E
Neuropharmacology
. 2025 Mar;
271:110391.
PMID: 40024472
Pro-inflammatory mediators can directly activate pain-sensing neurons, known as nociceptors. Additionally, these mediators can sensitise ion channels and receptors expressed by these cells through transcriptional and post-translational modulation, leading to...
2.
Pattison L, Rickman R, Hilton H, Dannawi M, Wijesinghe S, Ladds G, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(51):e2410653121.
PMID: 39661058
Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton-sensing GPCR,...
3.
Pattison L, Cloake A, Chakrabarti S, Hilton H, Rickman R, Higham J, et al.
Pain
. 2024 Mar;
165(8):1761-1773.
PMID: 38452214
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before...
4.
Perez-Sanchez J, Middleton S, Pattison L, Hilton H, Awadelkareem M, Zuberi S, et al.
Sci Transl Med
. 2023 Oct;
15(716):eadh3839.
PMID: 37792955
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic...
5.
Bohic M, Pattison L, Anissa Jhumka Z, Rossi H, Thackray J, Ricci M, et al.
Neuron
. 2023 Jul;
111(18):2811-2830.e8.
PMID: 37442132
Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting physiology, motor function, and motivation to engage in certain behaviors. The complexity of the pain state has...
6.
Urriola-Munoz P, Pattison L, Smith E
J Cell Physiol
. 2023 Feb;
238(4):761-775.
PMID: 36790936
The naked mole-rat (NMR, Heterocephalus glaber) is of significant interest to biogerontological research, rarely developing age-associated diseases, such as cancer. The transmembrane glycoprotein CD44 is upregulated in certain cancers and...
7.
Barker K, Higham J, Pattison L, Chessell I, Welsh F, Smith E, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Feb;
324(4):G250-G261.
PMID: 36749569
The effective management of visceral pain is a significant unmet clinical need for those affected by gastrointestinal diseases, such as inflammatory bowel disease (IBD). The rational design of novel analgesics...
8.
Ai M, Hotham W, Pattison L, Ma Q, Henson F, Smith E
Arthritis Rheumatol
. 2022 Sep;
75(3):352-363.
PMID: 36122169
Objective: Mesenchymal stem/stromal cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) have been reported to alleviate pain in patients with knee osteoarthritis (OA). We undertook this study to determine whether MSCs...
9.
Barker K, Higham J, Pattison L, Taylor T, Chessell I, Welsh F, et al.
J Physiol
. 2022 Jul;
600(16):3819-3836.
PMID: 35775903
Visceral pain is a leading cause of morbidity in gastrointestinal diseases, which is exacerbated by the gut-related side-effects of many analgesics. New treatments are needed and further understanding of the...
10.
Pattison L, Krock E, Svensson C, Smith E
Pain
. 2021 Feb;
162(3):714-717.
PMID: 33591110
No abstract available.