Ewan St John Smith
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Explore the profile of Ewan St John Smith including associated specialties, affiliations and a list of published articles.
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61
Citations
1225
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Recent Articles
1.
Aguilera-Lizarraga J, Lim T, Pattison L, Paine L, Bulmer D, Smith E
Neuropharmacology
. 2025 Mar;
271:110391.
PMID: 40024472
Pro-inflammatory mediators can directly activate pain-sensing neurons, known as nociceptors. Additionally, these mediators can sensitise ion channels and receptors expressed by these cells through transcriptional and post-translational modulation, leading to...
2.
Pattison L, Rickman R, Hilton H, Dannawi M, Wijesinghe S, Ladds G, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(51):e2410653121.
PMID: 39661058
Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton-sensing GPCR,...
3.
Meng M, Paine L, Sagnat D, Bello I, Oldroyd S, Javid F, et al.
Br J Pharmacol
. 2024 Dec;
182(6):1324-1340.
PMID: 39626870
Background And Purpose: Abdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated...
4.
GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of substance P release
Gupta R, Higham J, Pearce A, Urriola-Munoz P, Barker K, Paine L, et al.
Pain
. 2024 Oct;
166(3):596-613.
PMID: 39382322
The development of nonopioid analgesics for the treatment of abdominal pain is a pressing clinical problem. To address this, we examined the expression of G i/o -coupled receptors, which typically...
5.
Aguilera-Lizarraga J, Ritoux A, Bulmer D, Smith E
Am J Physiol Gastrointest Liver Physiol
. 2024 Jun;
327(2):G188-G201.
PMID: 38915279
The intestinal barrier plays a crucial role in homeostasis by both facilitating the absorption of nutrients and fluids and providing a tight shield to prevent the invasion by either pathogen...
6.
Pattison L, Cloake A, Chakrabarti S, Hilton H, Rickman R, Higham J, et al.
Pain
. 2024 Mar;
165(8):1761-1773.
PMID: 38452214
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before...
7.
Higham J, Smith E, Bulmer D
Mol Pain
. 2024 Feb;
20:17448069241230420.
PMID: 38379503
Ca imaging is frequently used in the investigation of sensory neuronal function and nociception. In vitro imaging of acutely dissociated sensory neurons using membrane-permeant fluorescent Ca indicators remains the most...
8.
Perez-Sanchez J, Middleton S, Pattison L, Hilton H, Awadelkareem M, Zuberi S, et al.
Sci Transl Med
. 2023 Oct;
15(716):eadh3839.
PMID: 37792955
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic...
9.
Parey E, Fernandez-Aroca D, Frost S, Uribarren A, Park T, Zottl M, et al.
Genome Res
. 2023 Aug;
33(9):1513-1526.
PMID: 37625847
Changes in gene regulation are thought to underlie most phenotypic differences between species. For subterranean rodents such as the naked mole-rat, proposed phenotypic adaptations include hypoxia tolerance, metabolic changes, and...
10.
Bohic M, Pattison L, Anissa Jhumka Z, Rossi H, Thackray J, Ricci M, et al.
Neuron
. 2023 Jul;
111(18):2811-2830.e8.
PMID: 37442132
Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting physiology, motor function, and motivation to engage in certain behaviors. The complexity of the pain state has...