Luke A ONeill
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Explore the profile of Luke A ONeill including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Galvan-Pena S, Carroll R, Newman C, Hinchy E, Palsson-McDermott E, Robinson E, et al.
Nat Commun
. 2019 Jan;
10(1):338.
PMID: 30659183
Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially potent at driving metabolic reprogramming, enhancing glycolysis and altering...
12.
Baardman J, Verberk S, Prange K, van Weeghel M, van der Velden S, Ryan D, et al.
Cell Rep
. 2018 Nov;
25(8):2044-2052.e5.
PMID: 30463003
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect...
13.
Gordon R, Albornoz E, Christie D, Langley M, Kumar V, Mantovani S, et al.
Sci Transl Med
. 2018 Nov;
10(465).
PMID: 30381407
Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α-synuclein-rich protein aggregates in...
14.
Olagnier D, Brandtoft A, Gunderstofte C, Villadsen N, Krapp C, Thielke A, et al.
Nat Commun
. 2018 Aug;
9(1):3506.
PMID: 30158636
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an...
15.
16.
Mills E, Ryan D, Prag H, Dikovskaya D, Menon D, Zaslona Z, et al.
Nature
. 2018 Mar;
556(7699):113-117.
PMID: 29590092
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for...
17.
Carroll R, Zaslona Z, Galvan-Pena S, Koppe E, Sevin D, Angiari S, et al.
J Biol Chem
. 2018 Feb;
293(15):5509-5521.
PMID: 29463677
Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents...
18.
19.
Palsson-McDermott E, Dyck L, Zaslona Z, Menon D, Mcgettrick A, Mills K, et al.
Front Immunol
. 2017 Oct;
8:1300.
PMID: 29081778
Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated with good clinical outcomes in a broad variety of malignancies. High levels of PD-L1 promote tumor...
20.
Netea M, Balkwill F, Chonchol M, Cominelli F, Donath M, Giamarellos-Bourboulis E, et al.
Nat Immunol
. 2017 Jul;
18(8):826-831.
PMID: 28722720
Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral...