Luke A Gilbert
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Explore the profile of Luke A Gilbert including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Khoroshkin M, Asarnow D, Zhou S, Navickas A, Winters A, Goudreau J, et al.
Nat Methods
. 2024 Jul;
21(9):1634-1645.
PMID: 39014073
RNA structural switches are key regulators of gene expression in bacteria, but their characterization in Metazoa remains limited. Here, we present SwitchSeeker, a comprehensive computational and experimental approach for systematic...
12.
Yan J, Oyler-Castrillo P, Ravisankar P, Ward C, Levesque S, Jing Y, et al.
Nature
. 2024 Apr;
628(8008):639-647.
PMID: 38570691
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3' ends of CRISPR-Cas guide RNAs. To identify cellular determinants of prime editing,...
13.
Wang S, Bohnert V, Joseph A, Sudaryo V, Skariah G, Swinderman J, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2313693120.
PMID: 38117852
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates...
14.
Schmidt R, Ward C, Dajani R, Armour-Garb Z, Ota M, Allain V, et al.
Nature
. 2023 Dec;
625(7996):805-812.
PMID: 38093011
CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell function and has nominated candidate targets for immunotherapies. However, new approaches are required to probe...
15.
Herken B, Wong G, Norman T, Gilbert L
bioRxiv
. 2023 Aug;
PMID: 37609173
A fundamental question in biology is how a limited number of genes combinatorially govern cellular responses to environmental changes. While the prevailing hypothesis is that relationships between genes, processes, and...
16.
Woo B, Moussavi-Baygi R, Karner H, Karimzadeh M, Garcia K, Joshi T, et al.
bioRxiv
. 2023 Jul;
PMID: 37398273
Large-scale sequencing efforts of thousands of tumor samples have been undertaken to understand the mutational landscape of the coding genome. However, the vast majority of germline and somatic variants occur...
17.
Wang S, Bohnert V, Joseph A, Sudaryo V, Swinderman J, Yu F, et al.
bioRxiv
. 2023 Jun;
PMID: 37333273
ENPP1 expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates the anticancer STING...
18.
Replogle J, Bonnar J, Pogson A, Liem C, Maier N, Ding Y, et al.
Elife
. 2022 Dec;
11.
PMID: 36576240
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell...
19.
Lou K, Wassarman D, Yang T, Paung Y, Zhang Z, OLoughlin T, et al.
Science
. 2022 Dec;
378(6624):1097-1104.
PMID: 36480603
The search for cell-permeable drugs has conventionally focused on low-molecular weight (MW), nonpolar, rigid chemical structures. However, emerging therapeutic strategies break traditional drug design rules by employing flexibly linked chemical...
20.
Sjostrom M, Zhao S, Levy S, Zhang M, Ning Y, Shrestha R, et al.
Cancer Res
. 2022 Oct;
82(21):3888-3902.
PMID: 36251389
Significance: In prostate cancer, 5-hydroxymethylcytosine delineates oncogene activation and stage-specific cell states and can be analyzed in liquid biopsies to detect cancer phenotypes. See related article by Wu and Attard,...