Lukas Steuernagel
Overview
Explore the profile of Lukas Steuernagel including associated specialties, affiliations and a list of published articles.
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12
Citations
145
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Recent Articles
1.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
639(8054):E17.
PMID: 40000749
No abstract available.
2.
Izawa S, Fusca D, Jiang H, Heilinger C, Hausen A, Wunderlich F, et al.
Cell Rep
. 2025 Feb;
44(2):115277.
PMID: 39946231
Orexin/hypocretin receptor type 2 (Ox2R), which is widely expressed in the brain, receives orexin signals and modulates sleep and metabolism. Ox2R selective agonists are currently under clinical trials for narcolepsy...
3.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
PMID: 39910307
The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions. However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged...
4.
Dodt S, Widdershooven N, Dreisow M, Weiher L, Steuernagel L, Wunderlich F, et al.
Nat Commun
. 2024 Jun;
15(1):5439.
PMID: 38937485
Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous signals shape...
5.
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Zhou X, Stine C, Prada P, Fusca D, Assoumou K, Dernic J, et al.
Nat Commun
. 2024 Jun;
15(1):5353.
PMID: 38918403
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action...
6.
Leon S, Simon V, Lee T, Steuernagel L, Clark S, Biglari N, et al.
Nat Commun
. 2024 Apr;
15(1):3443.
PMID: 38658557
The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to...
7.
De Solis A, Del Rio-Martin A, Radermacher J, Chen W, Steuernagel L, Bauder C, et al.
Nat Metab
. 2024 Feb;
6(3):473-493.
PMID: 38378998
Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine non-interacting recombinases to simultaneously express functionally opposing chemogenetic receptors in AgRP and POMC neurons for comparing...
8.
Hammerschmidt P, Steculorum S, Bandet C, Del Rio-Martin A, Steuernagel L, Kohlhaas V, et al.
Nat Commun
. 2023 Nov;
14(1):7824.
PMID: 38016943
Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained...
9.
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Zhou X, Stine C, Prada P, Fusca D, Assoumou K, Dernic J, et al.
bioRxiv
. 2023 Jun;
PMID: 37292957
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action...
10.
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, et al.
Cell Metab
. 2023 Apr;
35(5):786-806.e13.
PMID: 37075752
Autophagy represents a key regulator of aging and metabolism in sensing energy deprivation. We find that fasting in mice activates autophagy in the liver paralleled by activation of hypothalamic AgRP...