Jens C Bruning
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Explore the profile of Jens C Bruning including associated specialties, affiliations and a list of published articles.
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Articles
203
Citations
14674
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Recent Articles
1.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
639(8054):E17.
PMID: 40000749
No abstract available.
2.
Izawa S, Fusca D, Jiang H, Heilinger C, Hausen A, Wunderlich F, et al.
Cell Rep
. 2025 Feb;
44(2):115277.
PMID: 39946231
Orexin/hypocretin receptor type 2 (Ox2R), which is widely expressed in the brain, receives orexin signals and modulates sleep and metabolism. Ox2R selective agonists are currently under clinical trials for narcolepsy...
3.
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, et al.
Nature
. 2025 Feb;
PMID: 39910307
The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions. However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged...
4.
Amatruda M, Marechal D, Gacias M, Wentling M, Turpin-Nolan S, Morstein J, et al.
Glia
. 2024 Nov;
73(2):271-290.
PMID: 39489703
Ceramide C16 is a sphingolipid detected at high levels in several neurodegenerative disorders, including multiple sclerosis (MS). It can be generated de novo or from the hydrolysis of other sphingolipids,...
5.
Ardanaz C, de la Cruz A, Minhas P, Hernandez-Martin N, Pozo M, Valdecantos M, et al.
Sci Adv
. 2024 Oct;
10(42):eadp1115.
PMID: 39423276
Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, i.e., GLUT1, for brain glucose metabolism has...
6.
Dodt S, Widdershooven N, Dreisow M, Weiher L, Steuernagel L, Wunderlich F, et al.
Nat Commun
. 2024 Jun;
15(1):5439.
PMID: 38937485
Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous signals shape...
7.
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Zhou X, Stine C, Prada P, Fusca D, Assoumou K, Dernic J, et al.
Nat Commun
. 2024 Jun;
15(1):5353.
PMID: 38918403
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action...
8.
Henschke S, Nolte H, Magoley J, Kleele T, Brandt C, Hausen A, et al.
Science
. 2024 Apr;
384(6694):438-446.
PMID: 38662831
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that...
9.
Leon S, Simon V, Lee T, Steuernagel L, Clark S, Biglari N, et al.
Nat Commun
. 2024 Apr;
15(1):3443.
PMID: 38658557
The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to...
10.
Springer C, Binsch C, Weide D, Toska L, Cremer A, Backes H, et al.
Diabetes
. 2024 Apr;
73(7):1058-1071.
PMID: 38608276
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