Lukas C Kapitein
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Explore the profile of Lukas C Kapitein including associated specialties, affiliations and a list of published articles.
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115
Citations
5533
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Recent Articles
1.
Gros O, Passmore J, Borst N, Kutra D, Nijenhuis W, Fuqua T, et al.
PLoS Comput Biol
. 2025 Jan;
21(1):e1012349.
PMID: 39879256
The characterization of phenotypes in cells or organisms from microscopy data largely depends on differences in the spatial distribution of image intensity. Multiple methods exist for quantifying the intensity distribution...
2.
Kodba S, Oztop A, van Berkum E, Katrukha E, Iwanski M, Nijenhuis W, et al.
Cell Rep
. 2025 Jan;
44(2):115238.
PMID: 39854207
Abscission is the last step of cell division. It separates the two sister cells and consists of cutting the cytoplasmic bridge. Abscission is mediated by the ESCRT membrane remodeling machinery,...
3.
Nicolaou K, Passmore J, Kapitein L, Mulder B, Berger F
Mol Biol Cell
. 2025 Jan;
36(3):ar22.
PMID: 39785704
The cellular interior is a spatially complex environment shaped by nontrivial stochastic and biophysical processes. Within this complexity, spatial organizational principles-also called spatial phenotypes-often emerge with functional implications. However, identifying...
4.
de Jager L, Jansen K, Hoogebeen R, Akhmanova A, Kapitein L, Forster F, et al.
J Cell Biol
. 2024 Oct;
224(1).
PMID: 39387699
Microtubules are crucial in cells and are regulated by various mechanisms like posttranslational modifications, microtubule-associated proteins, and tubulin isoforms. Recently, the conformation of the microtubule lattice has also emerged as...
5.
Korsten G, Osinga M, Pelle R, Serweta A, Hoogenberg B, Kampinga H, et al.
J Cell Biol
. 2024 Aug;
223(11).
PMID: 39150509
Huntington's disease (HD) is caused by a polyglutamine expansion of the huntingtin protein, resulting in the formation of polyglutamine aggregates. The mechanisms of toxicity that result in the complex HD...
6.
Studying Selective Autophagy of Protein Aggregates Using Particles Induced by Multimerization (PIMs)
Korsten G, Kapitein L
Methods Mol Biol
. 2024 Aug;
2845:95-108.
PMID: 39115660
Selective autophagy of protein aggregates, called aggrephagy, is vital for maintaining cellular homeostasis. Classically, studying aggrephagy has been challenging due to the infrequent occurrence of autophagic events and the lack...
7.
Koppers M, Ozkan N, Nguyen H, Jurriens D, McCaughey J, Nguyen D, et al.
Dev Cell
. 2024 May;
59(16):2053-2068.e9.
PMID: 38815583
Local mRNA translation in axons is critical for the spatiotemporal regulation of the axonal proteome. A wide variety of mRNAs are localized and translated in axons; however, how protein synthesis...
8.
Iwanski M, Katrukha E, Kapitein L
Methods Mol Biol
. 2023 Oct;
2694:151-174.
PMID: 37824004
Microtubules play an essential role in many cellular functions, in part by serving as tracks for intracellular transport by kinesin and dynein. The ability of microtubules to fulfill this role...
9.
Damstra H, Passmore J, Serweta A, Koutlas I, Burute M, Meye F, et al.
Nat Methods
. 2023 Sep;
20(10):1573-1580.
PMID: 37723243
Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light microscopy by physically expanding biological specimen in three dimensions. Nonetheless, using ExM for quantitative or diagnostic...
10.
Damstra H, Mohar B, Eddison M, Akhmanova A, Kapitein L, Tillberg P
Bio Protoc
. 2023 Jul;
13(12):e4698.
PMID: 37397797
Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light microscopy that can be applied in both tissues and cells. In ExM, samples are embedded in...