Michel O Steinmetz
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Explore the profile of Michel O Steinmetz including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
7496
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Recent Articles
1.
Estevez-Gallego J, Blum T, Ruhnow F, Gili M, Speroni S, Garcia-Castellanos R, et al.
Nat Commun
. 2025 Mar;
16(1):2396.
PMID: 40064882
A critical feature of microtubules is their GTP cap, a stabilizing GTP-tubulin rich region at growing microtubule ends. Microtubules polymerized in the presence of GTP analogs or from GTP hydrolysis-deficient...
2.
Czub M, Uliana F, Grubic T, Padeste C, Rosowski K, Lorenz C, et al.
Nat Commun
. 2025 Jan;
16(1):1165.
PMID: 39885130
Microtubule plus-end tracking proteins (+TIPs) participate in nearly all microtubule-based cellular processes and have recently been proposed to function as liquid condensates. However, their formation and internal organization remain poorly...
3.
Iyer S, Chen F, Ogunmolu F, Moradi S, Volkov V, van Grinsven E, et al.
J Cell Biol
. 2025 Jan;
224(3.
PMID: 39847124
Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very slowly, but the underlying mechanisms are poorly...
4.
Herman J, Vanstreels E, Bardiot D, Prota A, Gaillard N, Gao L, et al.
PLoS One
. 2024 Nov;
19(11):e0307153.
PMID: 39509402
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel...
5.
Reynders M, Garscia M, Muller-Deku A, Wranik M, Krauskopf K, de la Osa de la Rosa L, et al.
Chem Sci
. 2024 Aug;
15(31):12301-12309.
PMID: 39118608
Azobenzene analogues of the tubulin polymerisation inhibitor combretastatin A4 (PSTs) were previously developed to optically control microtubule dynamics in living systems, with subsecond response time and single-cell spatial precision, by...
6.
Steinmetz M, Prota A
Curr Opin Struct Biol
. 2024 May;
87:102845.
PMID: 38805950
Microtubule-targeting agents (MTAs) have demonstrated remarkable efficacy as antitumor, antifungal, antiparasitic, and herbicidal agents, finding applications in the clinical, veterinary, and agrochemical industry. Recent advances in tubulin and microtubule structural...
7.
Abel A, Muhlethaler T, Dessin C, Schachtsiek T, Sammet B, Sharpe T, et al.
J Biol Chem
. 2024 May;
300(6):107363.
PMID: 38735475
Cryptophycins are microtubule-targeting agents (MTAs) that belong to the most potent antimitotic compounds known to date; however, their exact molecular mechanism of action remains unclear. Here, we present the 2.2 ...
8.
Homer J, Koelln R, Barrow A, Gialelis T, Boiarska Z, Steinohrt N, et al.
Chem Sci
. 2024 Mar;
15(11):3879-3892.
PMID: 38487227
Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and exceptional product yields, ASCC streamlines...
9.
Meier S, Steinmetz M, Barral Y
Trends Biochem Sci
. 2024 Feb;
49(4):318-332.
PMID: 38350804
To fulfill their actual cellular role, individual microtubules become functionally specialized through a broad range of mechanisms. The 'search and capture' model posits that microtubule dynamics and functions are specified...
10.
Wranik M, Kepa M, Beale E, James D, Bertrand Q, Weinert T, et al.
Nat Commun
. 2023 Dec;
14(1):7956.
PMID: 38042952
Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor...