Casper C Hoogenraad
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Explore the profile of Casper C Hoogenraad including associated specialties, affiliations and a list of published articles.
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218
Citations
12383
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Recent Articles
1.
Kahn O, Dominguez S, Glock C, Hayne M, Vito S, Sengupta Ghosh A, et al.
Cell Rep
. 2025 Mar;
44(3):115382.
PMID: 40056413
Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein that provides structural support for axons and is released into the extracellular space following neuronal injury. While NfL has been extensively...
2.
Freal A, Hoogenraad C
Neuron
. 2025 Feb;
113(5):649-669.
PMID: 39947181
The axon initial segment (AIS) is a highly specialized compartment in neurons that resides in between axonal and somatodendritic domains. The localization of the AIS in the proximal part of...
3.
Schauer S, Toth B, Lee J, Honigberg L, Ramakrishnan V, Jiang J, et al.
Alzheimers Dement
. 2024 Nov;
20(12):8855-8866.
PMID: 39513754
Introduction: Semorinemab, an anti-tau monoclonal antibody, was assessed in two Phase II trials for Alzheimer's disease (AD). Plasma and cerebrospinal fluid (CSF) biomarkers provided insights into the drug's potential mechanism...
4.
Shan X, Zhang A, Rezzonico M, Tsai M, Sanchez-Priego C, Zhang Y, et al.
Cell Rep Methods
. 2024 Sep;
4(9):100858.
PMID: 39255791
NGN2-driven induced pluripotent stem cell (iPSC)-to-neuron conversion is a popular method for human neurological disease modeling. In this study, we present a standardized approach for generating neurons utilizing clonal, targeted-engineered...
5.
Koppers M, Ozkan N, Nguyen H, Jurriens D, McCaughey J, Nguyen D, et al.
Dev Cell
. 2024 May;
59(16):2053-2068.e9.
PMID: 38815583
Local mRNA translation in axons is critical for the spatiotemporal regulation of the axonal proteome. A wide variety of mRNAs are localized and translated in axons; however, how protein synthesis...
6.
Hinz F, Villegas C, Roberts J, Yao H, Gaddam S, Delwig A, et al.
J Neurosci
. 2024 May;
44(24).
PMID: 38692735
Sterile alpha and TIR motif containing 1 (SARM1) is an inducible NADase that localizes to mitochondria throughout neurons and senses metabolic changes that occur after injury. Minimal proteomic changes are...
7.
Byrnes A, Roudnicky F, Gogineni A, Soung A, Xiong M, Hayne M, et al.
Cell Rep Methods
. 2024 Jan;
4(1):100673.
PMID: 38171361
While antisense oligonucleotides (ASOs) are used in the clinic, therapeutic development is hindered by the inability to assay ASO delivery and activity in vivo. Accordingly, we developed a dual-fluorescence, knockin...
8.
Dominguez S, Laufer B, Sengupta Ghosh A, Li Q, Ruggeri G, Emani M, et al.
iScience
. 2023 Nov;
26(11):108362.
PMID: 37965143
Heterozygous mutations in the granulin () gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Polymorphisms in have been associated with disease risk in mutation carriers...
9.
Adrian M, Weber M, Tsai M, Glock C, Kahn O, Phu L, et al.
Nat Commun
. 2023 Oct;
14(1):6322.
PMID: 37813836
Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to detect...
10.
Freal A, Jamann N, Ten Bos J, Jansen J, Petersen N, Ligthart T, et al.
Sci Adv
. 2023 Sep;
9(37):eadf3885.
PMID: 37713493
Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly...