Luis F Parada
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Explore the profile of Luis F Parada including associated specialties, affiliations and a list of published articles.
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129
Citations
10173
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Recent Articles
1.
Farouk Sait S, Tang K, Angus S, Brown R, Sun D, Xie X, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2407745121.
PMID: 39793045
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexisting benign lesions called...
2.
Chen Y, Iyer S, Hsieh D, Li B, Elias H, Wang T, et al.
Nature
. 2024 Nov;
636(8042):466-473.
PMID: 39567689
Glioblastoma is incurable and in urgent need of improved therapeutics. Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a...
3.
Xie X, Ganbold M, Li J, Lien M, Chipman M, Wang T, et al.
Neuron
. 2024 Nov;
112(24):4017-4032.e6.
PMID: 39510072
Glioblastoma (GBM) is an incurable disease with high intratumoral heterogeneity. Bioinformatic studies have examined transcriptional heterogeneity with differing conclusions. Here, we characterize GBM heterogeneity and highlight critical phenotypic and hierarchical...
4.
Chipman M, Wang Z, Sun D, Pedraza A, Bale T, Parada L
Proc Natl Acad Sci U S A
. 2023 Apr;
120(16):e2222084120.
PMID: 37040416
Macrophage targeting therapies have had limited clinical success in glioblastoma (GBM). Further understanding the GBM immune microenvironment is critical for refining immunotherapeutic approaches. Here, we use genetically engineered mouse models...
5.
Nguyen T, Wang W, Sternisha A, Corley C, Wang H, Wang X, et al.
Cell Chem Biol
. 2023 Feb;
30(2):214-229.e18.
PMID: 36758549
Glioblastoma (GBM) is an aggressive adult brain cancer with few treatment options due in part to the challenges of identifying brain-penetrant drugs. Here, we investigated the mechanism of MM0299, a...
6.
Nishijima E, Honda S, Kitamura Y, Namekata K, Kimura A, Guo X, et al.
Mol Ther
. 2022 Dec;
31(3):810-824.
PMID: 36463402
Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration. However, the transient nature of ligand-dependent activation limits its effectiveness. In this study, we solved this problem by inventing...
7.
Xie X, Laks D, Sun D, Ganbold M, Wang Z, Pedraza A, et al.
Dev Cell
. 2022 Jan;
57(1):32-46.e8.
PMID: 35016005
We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-proliferative therapies. Functional characterization of spontaneous glioblastomas from genetically engineered mice reveals essential quiescent stem-like cells that...
8.
Alcantara Llaguno S, Parada L
Curr Opin Neurol
. 2021 Sep;
34(6):868-874.
PMID: 34581301
Purpose Of Review: Cancer stem cells (CSCs) have been implicated in the hierarchical heterogeneity and treatment resistance of hematologic and solid tumor malignancies, including gliomas, for several decades now but...
9.
Sun D, Xie X, Zhang X, Wang Z, Farouk Sait S, Iyer S, et al.
Cell Stem Cell
. 2021 May;
28(8):1397-1410.e4.
PMID: 34010628
NF1-associated malignant peripheral nerve sheath tumors (MPNSTs) are the major cause of mortality in neurofibromatosis. MPNSTs arise from benign peripheral nerve plexiform neurofibromas that originate in the embryonic neural crest...
10.
Qin Y, Wong B, Zhong L, Geng F, Parada L, Wen D
CRISPR J
. 2021 Feb;
4(1):147-154.
PMID: 33567216
Mice derived entirely from embryonic stem (ES) cells can be generated through tetraploid complementation. Although XY male ES cell lines are commonly used in this system, occasionally, monosomic XO female...