Luis F Parada
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Explore the profile of Luis F Parada including associated specialties, affiliations and a list of published articles.
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129
Citations
10173
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Recent Articles
11.
Nagle V, Henry K, Hertz C, Graham M, Campos C, Parada L, et al.
Clin Cancer Res
. 2021 Jan;
27(7):1958-1966.
PMID: 33495310
Purpose: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Various immunotherapeutic approaches to improve patient survival are being developed, but the molecular mechanisms of immunotherapy resistance are...
12.
Xie X, Laks D, Sun D, Poran A, Laughney A, Wang Z, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(49):31448-31458.
PMID: 33229571
Adult neural stem cells (NSC) serve as a reservoir for brain plasticity and origin for certain gliomas. Lineage tracing and genomic approaches have portrayed complex underlying heterogeneity within the major...
13.
Wang Z, Sun D, Chen Y, Xie X, Shi Y, Tabar V, et al.
Cancer Cell
. 2020 Jul;
38(3):366-379.e8.
PMID: 32649888
Glioblastoma, the predominant adult malignant brain tumor, has been computationally classified into molecular subtypes whose functional relevance remains to be comprehensively established. Tumors from genetically engineered glioblastoma mouse models initiated...
14.
Rauen K, AlSaegh A, Ben-Shachar S, Berman Y, Blakeley J, Cordeiro I, et al.
Am J Med Genet A
. 2019 Mar;
179(6):1091-1097.
PMID: 30908877
The neurofibromatoses, which include neurofibromatosis type I (NF1), neurofibromatosis type II (NF2), and schwannomatosis, are a group of syndromes characterized by tumor growth in the nervous system. The RASopathies are...
15.
Shi Y, Lim S, Liang Q, Iyer S, Wang H, Wang Z, et al.
Nature
. 2019 Mar;
567(7748):341-346.
PMID: 30842654
Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare. Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human...
16.
Alcantara Llaguno S, Sun D, Pedraza A, Vera E, Wang Z, Burns D, et al.
Nat Neurosci
. 2019 Feb;
22(4):545-555.
PMID: 30778149
The contribution of lineage identity and differentiation state to malignant transformation is controversial. We have previously shown that adult neural stem and early progenitor cells give origin to glioblastoma. Here...
17.
Ma Z, Zang T, Birnbaum S, Wang Z, Johnson J, Zhang C, et al.
Nat Commun
. 2017 Nov;
8(1):1668.
PMID: 29162814
Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low doses produces both rapid and sustained antidepressant...
18.
Parada L, Dirks P, Wechsler-Reya R
J Clin Oncol
. 2017 Jun;
35(21):2428-2431.
PMID: 28640710
No abstract available.
19.
Alcantara Llaguno S, Parada L
Br J Cancer
. 2016 Nov;
115(12):1445-1450.
PMID: 27832665
The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development of...
20.
Alcantara Llaguno S, Xie X, Parada L
Cold Spring Harb Symp Quant Biol
. 2016 Nov;
81:31-36.
PMID: 27815542
The cellular origins and the mechanisms of progression, maintenance of tumorigenicity, and therapeutic resistance are central questions in the glioblastoma multiforme (GBM) field. Using tumor suppressor mouse models, our group...