Luca Beltrame
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Explore the profile of Luca Beltrame including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Potente S, Boscarino D, Paladin D, Marchini S, Beltrame L, Romualdi C
Brief Bioinform
. 2025 Jan;
26(1).
PMID: 39879385
Shallow whole-genome sequencing (sWGS) offers a cost-effective approach to detect copy number alterations (CNAs). However, there remains a gap for a standardized workflow specifically designed for sWGS analysis. To address...
2.
Bignotti E, Simeon V, Ardighieri L, Kuhn E, Marchini S, Califano D, et al.
Int J Cancer
. 2024 Oct;
156(5):1085-1096.
PMID: 39415516
To date, there are no biomarkers that define a patient subpopulation responsive to bevacizumab (BEV), an effective treatment option for advanced ovarian carcinoma (OC). In the context of the MITO16A/MaNGO...
3.
Sergi A, Beltrame L, Marchini S, Masseroli M
BMC Bioinformatics
. 2024 May;
25(1):180.
PMID: 38720249
Background: High-throughput sequencing (HTS) has become the gold standard approach for variant analysis in cancer research. However, somatic variants may occur at low fractions due to contamination from normal cells...
4.
Paracchini L, Mannarino L, Romualdi C, Zadro R, Beltrame L, Fuso Nerini I, et al.
Sci Transl Med
. 2023 Dec;
15(725):eadi2556.
PMID: 38055801
Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the highest mortality rate. In the work presented...
5.
Becchi T, Beltrame L, Mannarino L, Calura E, Marchini S, Romualdi C
J Biomed Inform
. 2023 Oct;
147:104529.
PMID: 37858853
Objective: Copy number variations (CNVs) play crucial roles in physiological and pathological processes, including cancer. However, the functional implications of somatic CNVs in tumor progression and evolution remain unclear. This...
6.
Velle A, Pesenti C, Grassi T, Beltrame L, Martini P, Jaconi M, et al.
Int J Cancer
. 2022 Dec;
152(9):1989-2001.
PMID: 36541726
isomiRs, the sequence-variants of microRNA, are known to be tissue and cell type specific but their physiological role is largely unknown. In our study, we explored for the first time...
7.
Paracchini L, Mannarino L, Beltrame L, Landoni F, Fruscio R, Grassi T, et al.
Cancers (Basel)
. 2022 Aug;
14(15).
PMID: 35954363
We have previously demonstrated that longitudinal untargeted analysis of plasma samples withdrawn from patients with high-grade serous ovarian cancer (HGS-EOC) can intercept the presence of molecular recurrence (TRm) earlier than...
8.
Salamone A, Terrone G, Di Sapia R, Balosso S, Ravizza T, Beltrame L, et al.
Neurobiol Dis
. 2022 Aug;
173:105835.
PMID: 35932989
Therapies for epilepsy mainly provide symptomatic control of seizures since most of the available drugs do not target disease mechanisms. Moreover, about one-third of patients fail to achieve seizure control....
9.
Mannarino L, Mirimao F, Panini N, Paracchini L, Marchini S, Beltrame L, et al.
Cell Death Dis
. 2022 Jul;
13(7):612.
PMID: 35840560
Although clinical antitumor activity of Tumor Treating Fields (TTFields) has been reported in malignant pleural mesothelioma (MPM) patients, the mechanisms behind the different selectivity displayed by the various MPM histotypes...
10.
Pesenti C, Beltrame L, Velle A, Fruscio R, Jaconi M, Borella F, et al.
Eur J Cancer
. 2022 Jun;
171:85-95.
PMID: 35714451
Background: Stage I epithelial ovarian cancer (EOC) encompasses five histologically different subtypes of tumors confined to the ovaries with a generally favorable prognosis. Despite the intrinsic heterogeneity, all stage I...