Luc Schoonjans
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Explore the profile of Luc Schoonjans including associated specialties, affiliations and a list of published articles.
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47
Citations
4605
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Recent Articles
11.
Leslie J, Macia M, Luli S, Worrell J, Reilly W, Paish H, et al.
Nat Metab
. 2020 Nov;
2(11):1350-1367.
PMID: 33168981
Fibrosis is a common pathological feature of chronic disease. Deletion of the NF-κB subunit c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is unresolved. Using...
12.
DAnna F, Van Dyck L, Xiong J, Zhao H, Berrens R, Qian J, et al.
Genome Biol
. 2020 Jul;
21(1):182.
PMID: 32718321
Background: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell...
13.
Taverna F, Goveia J, Karakach T, Khan S, Rohlenova K, Treps L, et al.
Nucleic Acids Res
. 2020 May;
48(W1):W385-W394.
PMID: 32392297
The amount of biological data, generated with (single cell) omics technologies, is rapidly increasing, thereby exacerbating bottlenecks in the data analysis and interpretation of omics experiments. Data mining platforms that...
14.
Rohlenova K, Goveia J, Garcia-Caballero M, Subramanian A, Kalucka J, Treps L, et al.
Cell Metab
. 2020 Apr;
31(4):862-877.e14.
PMID: 32268117
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor angiogenesis and choroidal neovascularization (CNV), but little is known about individual EC metabolic transcriptomes. By single-cell RNA...
15.
Goveia J, Rohlenova K, Taverna F, Treps L, Conradi L, Pircher A, et al.
Cancer Cell
. 2020 Mar;
37(3):421.
PMID: 32183954
No abstract available.
16.
Kalucka J, de Rooij L, Goveia J, Rohlenova K, Dumas S, Meta E, et al.
Cell
. 2020 Feb;
180(4):764-779.e20.
PMID: 32059779
The heterogeneity of endothelial cells (ECs) across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomes from 11 mouse tissues and identified 78 EC subclusters, including Aqp7...
17.
Goveia J, Rohlenova K, Taverna F, Treps L, Conradi L, Pircher A, et al.
Cancer Cell
. 2020 Jan;
37(1):21-36.e13.
PMID: 31935371
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial...
18.
Dumas S, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha N, et al.
J Am Soc Nephrol
. 2019 Dec;
31(1):118-138.
PMID: 31818909
Background: Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions and support specific kidney processes. However, the heterogeneous phenotypes of these cells remain...
19.
Jain I, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz G, Ast T, et al.
Cell Metab
. 2019 Aug;
30(4):824-832.e3.
PMID: 31402314
Leigh syndrome is a devastating mitochondrial disease for which there are no proven therapies. We previously showed that breathing chronic, continuous hypoxia can prevent and even reverse neurological disease in...
20.
Khan S, Taverna F, Rohlenova K, Treps L, Geldhof V, de Rooij L, et al.
Nucleic Acids Res
. 2018 Oct;
47(D1):D736-D744.
PMID: 30357379
Endothelial cells (ECs) line blood vessels, regulate homeostatic processes (blood flow, immune cell trafficking), but are also involved in many prevalent diseases. The increasing use of high-throughput technologies such as...