Luc Bousset
Overview
Explore the profile of Luc Bousset including associated specialties, affiliations and a list of published articles.
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Articles
100
Citations
5095
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Recent Articles
1.
Bouvier-Muller A, Fourmy D, Fenyi A, Bousset L, Melki R, Duconge F
Nucleic Acids Res
. 2024 Jun;
52(14):8072-8085.
PMID: 38917326
Synucleinopathies, including dementia with Lewy bodies (DLB), Parkinson's disease (PD), and multiple system atrophy (MSA), are characterized by the presence of α-synuclein (α-syn) aggregates in the central nervous system. Recent...
2.
Celestine M, Jacquier-Sarlin M, Borel E, Petit F, Lante F, Bousset L, et al.
Mol Psychiatry
. 2024 Jun;
29(12):3707-3721.
PMID: 38871852
The amyloid cascade hypothesis assumes that the development of Alzheimer's disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid (Aβ) accumulation leads to Tau pathology and neuronal damages....
3.
Courte J, Le N, Pan T, Bousset L, Melki R, Villard C, et al.
Cell Mol Life Sci
. 2023 Sep;
80(10):284.
PMID: 37688644
Alpha-synuclein (aSyn) aggregation spreads between cells and underlies the progression of neuronal lesions in the brain of patients with synucleinopathies such as Parkinson's diseases. The mechanisms of cell-to-cell propagation of...
4.
Celestine M, Jacquier-Sarlin M, Borel E, Petit F, Perot J, Herard A, et al.
Acta Neuropathol Commun
. 2023 Apr;
11(1):66.
PMID: 37087498
Alzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly...
5.
Fayard A, Fenyi A, Lavisse S, Dovero S, Bousset L, Bellande T, et al.
Neurobiol Dis
. 2023 Mar;
180:106086.
PMID: 36933673
The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical...
6.
Gribaudo S, Bousset L, Courte J, Melki R, Peyrin J, Perrier A
Methods Mol Biol
. 2022 Oct;
2551:357-378.
PMID: 36310215
Aggregated alpha-synuclein (α-Syn) in neurons is a hallmark of Parkinson's disease (PD) and other synucleinopathies. Recent advances (1) in the production and purification of synthetic assemblies of α-Syn, (2) in...
7.
Bousset L, Alik A, Arteni A, Bockmann A, Meier B, Melki R
Methods Mol Biol
. 2022 Oct;
2551:345-355.
PMID: 36310214
The human α-synuclein protein, identified as one of the main markers of Parkinson's disease, is a 140-amino acid thermostable protein that can easily be overexpressed in E. coli. The purification...
8.
Marchi P, Marrone L, Brasseur L, Coens A, Webster C, Bousset L, et al.
Life Sci Alliance
. 2022 May;
5(9).
PMID: 35568435
Dipeptide repeat (DPR) proteins are aggregation-prone polypeptides encoded by the pathogenic GGGGCC repeat expansion in the gene, the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. In...
9.
De Giorgi F, Abdul-Shukkoor M, Kashyrina M, Largitte L, De Nuccio F, Kauffmann B, et al.
Biomolecules
. 2022 Mar;
12(3).
PMID: 35327628
The distinct neuropathological features of the different α-Synucleinopathies, as well as the diversity of the α-Synuclein (α-Syn) intracellular inclusion bodies observed in post mortem brain sections, are thought to reflect...
10.
Burbidge K, Rademacher D, Mattick J, Zack S, Grillini A, Bousset L, et al.
Autophagy
. 2021 Oct;
18(5):1020-1048.
PMID: 34612142
Numerous lines of evidence support the premise that the misfolding and subsequent accumulation of SNCA/α-synuclein (synuclein alpha) is responsible for the underlying neuronal pathology observed in Parkinson disease (PD) and...