Luc Bousset
Overview
Explore the profile of Luc Bousset including associated specialties, affiliations and a list of published articles.
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100
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5095
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Recent Articles
11.
Scheiblich H, Dansokho C, Mercan D, Schmidt S, Bousset L, Wischhof L, et al.
Cell
. 2021 Sep;
184(20):5089-5106.e21.
PMID: 34555357
Microglia are the CNS resident immune cells that react to misfolded proteins through pattern recognition receptor ligation and activation of inflammatory pathways. Here, we studied how microglia handle and cope...
12.
Scheiblich H, Bousset L, Schwartz S, Griep A, Latz E, Melki R, et al.
J Immunol
. 2021 Sep;
207(8):2143-2154.
PMID: 34507948
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder and is characterized by the formation of cellular inclusions inside neurons that are rich in an abnormal form of...
13.
Tanudjojo B, Shaikh S, Fenyi A, Bousset L, Agarwal D, Marsh J, et al.
Nat Commun
. 2021 Jun;
12(1):3817.
PMID: 34155194
α-Synuclein is critical in the pathogenesis of Parkinson's disease and related disorders, yet it remains unclear how its aggregation causes degeneration of human dopaminergic neurons. In this study, we induced...
14.
Russ K, Teku G, Bousset L, Redeker V, Piel S, Savchenko E, et al.
Cell Rep
. 2021 Mar;
34(12):108895.
PMID: 33761362
Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human astrocytes treated with...
15.
Matsuo K, Kawahata I, Melki R, Bousset L, Owada Y, Fukunaga K
Brain Res
. 2021 Feb;
1760:147383.
PMID: 33636166
Accumulation and aggregation of α-synuclein (αSyn) trigger neuronal loss in the substantia nigra pars compacta (SNpc), which in turn causes motor symptoms in Parkinson's disease. We previously demonstrated that fatty...
16.
Fenyi A, Duyckaerts C, Bousset L, Braak H, Del Tredici K, Melki R, et al.
Cells
. 2021 Jan;
10(1).
PMID: 33445653
We investigated α-synuclein's (αSyn) seeding activity in tissue from the brain and enteric nervous system. Specifically, we assessed the seeding propensity of pathogenic αSyn in formalin-fixed tissue from the gastric...
17.
Guo J, Yue F, Song D, Bousset L, Liang X, Tang J, et al.
Cell Death Dis
. 2021 Jan;
12(1):81.
PMID: 33441545
Iron deposition is present in main lesion areas in the brains of patients with Parkinson's disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and...
18.
Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, et al.
Biomedicines
. 2021 Jan;
9(1).
PMID: 33429895
α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson's disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate...
19.
Matsuo K, Yabuki Y, Melki R, Bousset L, Owada Y, Fukunaga K
Int J Mol Sci
. 2021 Jan;
22(1).
PMID: 33401521
In synucleinopathies, while motor symptoms are thought to be attributed to the accumulation of misfolded α-synuclein (αSyn) in nigral dopaminergic neurons, it remains to be elucidated how cognitive decline arises....
20.
Makky A, Bousset L, Madiona K, Melki R
Biophys J
. 2020 Nov;
119(12):2497-2507.
PMID: 33217380
The amyloid fibrillar form of the protein Tau is involved in a number of neurodegenerative diseases, also known as tauopathies. In this work, six different fibrillar Tau isoforms were assembled...