Louis Locco
Overview
Explore the profile of Louis Locco including associated specialties, affiliations and a list of published articles.
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7
Citations
208
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0
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Recent Articles
1.
Pertusi D, ODonnell G, Homsher M, Solly K, Patel A, Stahler S, et al.
SLAS Discov
. 2017 Apr;
22(8):995-1006.
PMID: 28426940
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions...
2.
Stec E, Locco L, Szymanski S, Bartz S, Toniatti C, Needham R, et al.
J Biomol Screen
. 2012 Jul;
17(10):1316-28.
PMID: 22786893
Gene silencing by RNA interference has become a powerful tool to help identify genes that regulate biological processes. However, the complexity of the biology probed and the incomplete validation of...
3.
Chung N, Marine S, Smith E, Liehr R, Smith S, Locco L, et al.
Assay Drug Dev Technol
. 2010 Jun;
8(3):286-94.
PMID: 20578927
High-throughput siRNA screens are now widely used for identifying novel drug targets and mapping disease pathways. Despite their popularity, there remain challenges related to data variability, primarily due to measurement...
4.
Chung N, Zhang X, Kreamer A, Locco L, Kuan P, Bartz S, et al.
J Biomol Screen
. 2008 Jan;
13(2):149-58.
PMID: 18216396
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small...
5.
Chung N, Locco L, Huff K, Bartz S, Linsley P, Ferrer M, et al.
J Biomol Screen
. 2008 Jan;
13(2):142-8.
PMID: 18216392
RNA interference (RNAi), combined with the availability of genome sequences, provides an unprecedented opportunity for the massive and parallel investigations of gene function. Small interfering RNA (siRNA) represents a popular...
6.
Bartz S, Zhang Z, Burchard J, Imakura M, Martin M, Palmieri A, et al.
Mol Cell Biol
. 2006 Sep;
26(24):9377-86.
PMID: 17000754
RNA interference technology allows the systematic genetic analysis of the molecular alterations in cancer cells and how these alterations affect response to therapies. Here we used small interfering RNA (siRNA)...
7.
Sun W, Cama L, Birzin E, Warrier S, Locco L, Mosley R, et al.
Bioorg Med Chem Lett
. 2006 Jan;
16(6):1468-72.
PMID: 16412638
A series of 6H-benzo[c]chromen-6-one and 6H-benzo[c]chromene derivatives were prepared, and the affinity and selectivity for ERalpha and ERbeta was measured. Many of the analogs were found to be potent and...