Steven Bartz
Overview
Explore the profile of Steven Bartz including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
437
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0
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Recent Articles
1.
Jensen K, Tadin-Strapps M, Wang S, Hubert J, Kan Y, Ma Y, et al.
J Lipid Res
. 2016 Oct;
57(12):2150-2162.
PMID: 27707816
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription...
2.
Hamza M, Kumar C, Chia S, Anandalakshmi V, Boo N, Strapps W, et al.
Atherosclerosis
. 2015 Aug;
242(2):383-95.
PMID: 26275376
The greater genomic conservation between humans and non-human primates (NHP) enables target validation studies for developing of therapeutic strategies for human diseases. Together with predicting activity and potential adverse clinical...
3.
Olearczyk J, Gao S, Eybye M, Yendluri S, Andrews L, Bartz S, et al.
Hypertens Res
. 2013 Dec;
37(5):405-12.
PMID: 24335718
Angiotensinogen (AGT) is the precursor of active vasoconstrictive octapeptide angiotensin II (Ang II) in the renin-angiotensin-aldosterone system. Blocking the AGT-converting enzymes in the pathway and the Ang II receptor through...
4.
Lindow M, Vornlocher H, Riley D, Kornbrust D, Burchard J, Whiteley L, et al.
Nat Biotechnol
. 2012 Oct;
30(10):920-3.
PMID: 23051805
No abstract available.
5.
Chung N, Zhang X, Kreamer A, Locco L, Kuan P, Bartz S, et al.
J Biomol Screen
. 2008 Jan;
13(2):149-58.
PMID: 18216396
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small...
6.
Chung N, Locco L, Huff K, Bartz S, Linsley P, Ferrer M, et al.
J Biomol Screen
. 2008 Jan;
13(2):142-8.
PMID: 18216392
RNA interference (RNAi), combined with the availability of genome sequences, provides an unprecedented opportunity for the massive and parallel investigations of gene function. Small interfering RNA (siRNA) represents a popular...
7.
Li L, Zhang L, Zhang X, Yan Q, Minamishima Y, Olumi A, et al.
Mol Cell Biol
. 2007 May;
27(15):5381-92.
PMID: 17526729
Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL...
8.
Yan Q, Bartz S, Mao M, Li L, Kaelin Jr W
Mol Cell Biol
. 2007 Jan;
27(6):2092-102.
PMID: 17220275
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha subunit and a beta subunit, that controls cellular responses to hypoxia. HIFalpha contains two transcriptional activation domains called...
9.
Majercak J, Ray W, Espeseth A, Simon A, Shi X, Wolffe C, et al.
Proc Natl Acad Sci U S A
. 2006 Nov;
103(47):17967-72.
PMID: 17098871
Rare familial forms of Alzheimer's disease (AD) are thought to be caused by elevated proteolytic production of the Abeta42 peptide from the beta-amyloid-precursor protein (APP). Although the pathogenesis of the...
10.
Espeseth A, Huang Q, Gates A, Xu M, Yu Y, Simon A, et al.
Mol Cell Neurosci
. 2006 Sep;
33(3):227-35.
PMID: 16978875
Proteolysis of beta-amyloid precursor protein (APP) into amyloid beta peptide (Abeta) by beta- and gamma-secretases is a critical step in the pathogenesis of Alzheimer's Disease (AD), but the pathways regulating...