Loretta Dorstyn
Overview
Explore the profile of Loretta Dorstyn including associated specialties, affiliations and a list of published articles.
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21
Citations
641
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Recent Articles
1.
Umargamwala R, Manning J, Dorstyn L, Denton D, Kumar S
Cells
. 2024 Feb;
13(4.
PMID: 38391960
Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the...
2.
Kumar S, Dorstyn L, Lim Y
Biochem Soc Trans
. 2021 Dec;
50(1):33-45.
PMID: 34940803
Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of apoptotic cell death and in regulating inflammation. This article focuses primarily on the evolutionarily conserved function...
3.
Lim Y, Dorstyn L, Kumar S
Exp Mol Med
. 2021 Apr;
53(4):517-527.
PMID: 33854186
Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3...
4.
Lim Y, De Bellis D, Sandow J, Capalbo L, DAvino P, Murphy J, et al.
Cell Death Differ
. 2020 Aug;
28(1):349-366.
PMID: 32811973
Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
5.
Dorstyn L, Tvorogov D, Malek S, Robinson N
Cell Death Dis
. 2020 Mar;
11(3):162.
PMID: 32123157
No abstract available.
6.
Dorstyn L, Hackett-Jones E, Nikolic A, Norris M, Lim Y, Toubia J, et al.
Cell Death Dis
. 2019 Jan;
10(2):56.
PMID: 30670683
Caspase-2 is a highly conserved cysteine protease with roles in apoptosis and tumor suppression. Our recent findings have also demonstrated that the tumor suppression function of caspase-2 is context specific....
7.
Lim Y, De Bellis D, Dorstyn L, Kumar S
Cell Death Differ
. 2018 Aug;
25(11):2050-2052.
PMID: 30082771
No abstract available.
8.
Dorstyn L, Akey C, Kumar S
Cell Death Differ
. 2018 May;
25(7):1194-1208.
PMID: 29765111
The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. Biochemical and structural studies in the past two decades have extended our understanding of...
9.
Wilson C, Nikolic A, Kentish S, Keller M, Hatzinikolas G, Dorstyn L, et al.
Cell Death Dis
. 2017 Oct;
8(10):e3136.
PMID: 29072701
Caspase-2 has been shown to be involved in metabolic homeostasis. Here, we show that caspase-2 deficiency alters basal energy metabolism by shifting the balance in fuel choice from fatty acid...
10.
Dawar S, Shahrin N, Sladojevic N, DAndrea R, Dorstyn L, Hiwase D, et al.
Cell Death Dis
. 2016 Dec;
7(12):e2509.
PMID: 27906175
The apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some human malignancies. Caspase-2-deficient mice develop normally but...