The P53-caspase-2 Axis in the Cell Cycle and DNA Damage Response

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2021 Apr 15

PMID 33854186

Citations 18

Authors

Yoon Lim

Loretta Dorstyn

Sharad Kumar

Affiliations

Soon will be listed here.

Abstract

Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression.

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