Christopher W Akey
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Explore the profile of Christopher W Akey including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1703
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Recent Articles
1.
Akey C, Echeverria I, Ouch C, Nudelman I, Shi Y, Wang J, et al.
Mol Cell
. 2023 Sep;
83(18):3283-3302.e5.
PMID: 37738963
Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules. Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D density maps from cryogenic electron...
2.
Akey C, Singh D, Ouch C, Echeverria I, Nudelman I, Varberg J, et al.
Cell
. 2022 Jan;
185(2):361-378.e25.
PMID: 34982960
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner ring is resolved by cryo-EM at...
3.
Dorstyn L, Akey C, Kumar S
Cell Death Differ
. 2018 May;
25(7):1194-1208.
PMID: 29765111
The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. Biochemical and structural studies in the past two decades have extended our understanding of...
4.
Kim S, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, et al.
Nature
. 2018 Mar;
555(7697):475-482.
PMID: 29539637
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural...
5.
Mendez D, Akey I, Akey C, Kranz R
Biochemistry
. 2017 May;
56(22):2766-2769.
PMID: 28510448
Cytochrome c (cyt c) has two important roles in vertebrates: mitochondrial electron transport and activating the intrinsic cell death pathway (apoptosis). To initiate cell death, cyt c dissociates from the...
6.
Cheng T, Akey I, Yuan S, Yu Z, Ludtke S, Akey C
Structure
. 2016 Dec;
25(1):40-52.
PMID: 27916517
In Drosophila, the Apaf-1-related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near-atomic structure of Dark double rings using cryo-electron microscopy. We then...
7.
Cheng T, Hong C, Akey I, Yuan S, Akey C
Elife
. 2016 Oct;
5.
PMID: 27697150
In response to cell death signals, an active apoptosome is assembled from Apaf-1 and procaspase-9 (pc-9). Here we report a near atomic structure of the active human apoptosome determined by...
8.
Park E, Menetret J, Gumbart J, Ludtke S, Li W, Whynot A, et al.
Nature
. 2013 Oct;
506(7486):102-6.
PMID: 24153188
Many secretory proteins are targeted by signal sequences to a protein-conducting channel, formed by prokaryotic SecY or eukaryotic Sec61 complexes, and are translocated across the membrane during their synthesis. Crystal...
9.
DBrot A, Chen P, Vaishnav M, Yuan S, Akey C, Abrams J
Genes Dev
. 2013 Aug;
27(15):1650-5.
PMID: 23913920
It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts...
10.
Farelli J, Gumbart J, Akey I, Hempstead A, Amyot W, Head J, et al.
Structure
. 2013 Jul;
21(8):1361-73.
PMID: 23850453
A Type 4b secretion system (T4bSS) is required for Legionella growth in alveolar macrophages. IcmQ associates with IcmR, binds to membranes, and has a critical role in the T4bSS. We...