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» Authors » Lorene Penazzi

Lorene Penazzi

Explore the profile of Lorene Penazzi including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 130
Followers 0
Related Specialties
Neurology
Pharmacology
Molecular Biology
Top 10 Co-Authors
Lidia Bakota
Roland Brandt
Nataliya Golovyashkina
Amos B Smith 3rd
Frederik Sundermann
Carlo Ballatore
Brigitte Cosquer
Alexandra Barbelivien
Bastian David
Lars Lewejohann
Published In
Neuropharmacology
Epilepsia
Mol Neurodegener
Int Rev Cell Mol Biol
Behav Brain Res
Affiliations
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Recent Articles
1.
Chronic Presence of Oligomeric Aβ Differentially Modulates Spine Parameters in the Hippocampus and Cortex of Mice With Low APP Transgene Expression
Hrynchak M, Rierola M, Golovyashkina N, Penazzi L, Pump W, David B, et al.
Front Synaptic Neurosci . 2020 May; 12:16. PMID: 32390822
Alzheimer's disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligomeric amyloid-β (Aβ) is thought to play a causative role in this disease, which eventually leads to...
2.
DMSO modulates CNS function in a preclinical Alzheimer's disease model
Penazzi L, Lorengel J, Sundermann F, Golovyashkina N, Marre S, Mathis C, et al.
Neuropharmacology . 2016 Nov; 113(Pt A):434-444. PMID: 27773645
DMSO has a widespread use as a vehicle for water-insoluble therapeutic drug candidates but may also exert disease-relevant pharmacological effects by itself. However, its influence on the CNS has hardly...
3.
Microtubule Dynamics in Neuronal Development, Plasticity, and Neurodegeneration
Penazzi L, Bakota L, Brandt R
Int Rev Cell Mol Biol . 2016 Jan; 321:89-169. PMID: 26811287
Neurons are the basic information-processing units of the nervous system. In fulfilling their task, they establish a structural polarity with an axon that can be over a meter long and...
4.
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D
Penazzi L, Tackenberg C, Ghori A, Golovyashkina N, Niewidok B, Selle K, et al.
Neuropharmacology . 2016 Jan; 105:84-95. PMID: 26772969
Dendritic spines represent the major postsynaptic input of excitatory synapses. Loss of spines and changes in their morphology correlate with cognitive impairment in Alzheimer's disease (AD) and are thought to...
5.
Exposure to an enriched environment up to middle age allows preservation of spatial memory capabilities in old age
Fuchs F, Cosquer B, Penazzi L, Mathis C, Kelche C, Majchrzak M, et al.
Behav Brain Res . 2015 Nov; 299:1-5. PMID: 26611562
In rats, some cognitive capabilities, like spatial learning and memory, are preserved from age-related decline by whole adult life enriched environment (EE) exposure. However, to which extent late EE contributes...
6.
Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes
Golovyashkina N, Penazzi L, Ballatore C, Smith 3rd A, Bakota L, Brandt R
Mol Neurodegener . 2015 Nov; 10:60. PMID: 26541821
Background: Dendritic simplification, a key feature of the neurodegenerative triad of Alzheimer's disease (AD) in addition to spine changes and neuron loss, occurs in a region-specific manner. However, it is...
7.
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus
Faure J, Akimana G, Carneiro J, Cosquer B, Ferrandon A, Geiger K, et al.
Epilepsia . 2013 May; 54(7):1203-13. PMID: 23663139
Purpose: Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of...