Lorella Pasquinucci
Overview
Explore the profile of Lorella Pasquinucci including associated specialties, affiliations and a list of published articles.
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53
Citations
412
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Recent Articles
1.
Cosentino G, Dichiara M, Costanzo G, Coco A, Pasquinucci L, Marrazzo A, et al.
ChemMedChem
. 2025 Jan;
:e202401015.
PMID: 39887934
This study presents a series of tetrahydropyrrolo[3,4-c]pyrazole-based compounds designed as sigma-1 receptor (S1R) ligands, focusing on optimizing affinity and reducing off-target effects. We synthesized various derivatives from commercially available precursors...
2.
Buccheri R, Coco A, Pasquinucci L, Amata E, Marrazzo A, Rescifina A
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859564
Precise binding free-energy predictions for ligands targeting metalloproteins, especially zinc-containing histone deacetylase (HDAC) enzymes, require specialized computational approaches due to the unique interactions at metal-binding sites. This study evaluates a...
3.
Costanzo G, Cosentino G, Grasso M, Patamia V, Zuccala S, Coco A, et al.
RSC Med Chem
. 2025 Jan;
PMID: 39777289
Inflammatory pain represents one of the unmet clinical needs for patients, as conventional therapies cause several side effects. Recently, new targets involved in inflammatory pain modulation have been identified, including...
4.
Costanzo G, Coco A, Cosentino G, Patamia V, Parenti C, Amata E, et al.
Chem Biol Drug Des
. 2024 Dec;
104(6):e70037.
PMID: 39726303
Suitable structural modifications of the functional groups at N-substituent of (-)-cis-N-normetazocine nucleus modulate the affinity and activity profile of related ligands toward opioid receptors. Our research group has developed several...
5.
Cosentino G, Dichiara M, Ambrosio F, Leotta C, Costa G, Procopio F, et al.
Eur J Med Chem
. 2024 Nov;
281:117037.
PMID: 39547082
The design and synthesis of a series of piperidine and piperazine-based derivatives as selective sigma receptor (SR) ligands associated with analgesic activity, are the focus of this work. In this...
6.
Costanzo G, Cosentino G, Pasquinucci L, Amata E, Schepmann D, Wunsch B
ChemMedChem
. 2024 Sep;
19(24):e202400596.
PMID: 39236252
Enantiomerically pure 4-hydroxymorphan-7-ones were prepared in two steps from the natural product (R)-carvone. At first, the isopropenyl moiety of (R)-carvone was converted into the epoxide 7. A Domino reaction consisting...
7.
Denaro S, DAprile S, Torrisi F, Zappala A, Marrazzo A, Al-Khrasani M, et al.
Inflamm Res
. 2024 Aug;
73(10):1711-1726.
PMID: 39095656
Background And Objective: Neuropathic pain is a chronic condition characterized by aberrant signaling within the somatosensory system, affecting millions of people worldwide with limited treatment options. Herein, we aim at...
8.
Turnaturi R, Piana S, Spoto S, Costanzo G, Reina L, Pasquinucci L, et al.
Molecules
. 2024 Feb;
29(4).
PMID: 38398566
Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market,...
9.
Dichiara M, Cosentino G, Giordano G, Pasquinucci L, Marrazzo A, Costanzo G, et al.
Expert Opin Drug Discov
. 2023 Dec;
19(3):317-329.
PMID: 38145409
Introduction: With the increasing incidence and prevalence of neurological disorders globally, there is a paramount need for new pharmacotherapies. BBB effectively protects the brain but raises a profound challenge to...
10.
Denaro S, Pasquinucci L, Turnaturi R, Alberghina C, Longhitano L, Giallongo S, et al.
Mol Neurobiol
. 2023 Nov;
61(5):2672-2685.
PMID: 37922065
Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an injury or disease of the somatosensory nervous system, which induces abnormal painful sensations including allodynia...