Orazio Prezzavento
Overview
Explore the profile of Orazio Prezzavento including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
610
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Recent Articles
1.
Kostenko A, Prezzavento O, de Leo G, DArco D, Gulino R, Caccamo A, et al.
J Alzheimers Dis
. 2024 Sep;
101(3):797-811.
PMID: 39240642
Background: Sigma-1 receptors are highly expressed in brain areas related to cognitive function and are a promising target for anti-amnesic treatments. We previously showed that activation of sigma-1 receptors by...
2.
Longhitano L, Castruccio Castracani C, Tibullo D, Avola R, Viola M, Russo G, et al.
Oncotarget
. 2024 Mar;
15:199.
PMID: 38484150
No abstract available.
3.
Heiss K, Vanella L, Murabito P, Prezzavento O, Marrazzo A, Castruccio Castracani C, et al.
Neurosci Lett
. 2023 Apr;
807:137247.
PMID: 37119692
No abstract available.
4.
Barbaraci C, Giurdanella G, Leotta C, Longo A, Amata E, Dichiara M, et al.
J Med Chem
. 2021 Sep;
64(18):13622-13632.
PMID: 34477381
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. , a prodrug...
5.
Romeo G, Bonanno F, Wilson L, Arena E, Modica M, Pittala V, et al.
ACS Chem Neurosci
. 2021 May;
12(11):2003-2012.
PMID: 34019387
σ-1 receptors (σR) modulate nociceptive signaling, driving the search for selective antagonists to take advantage of this promising target to treat pain. In this study, a new series of benzylpiperazinyl...
6.
Amata E, Dichiara M, Gentile D, Marrazzo A, Turnaturi R, Arena E, et al.
ACS Med Chem Lett
. 2020 May;
11(5):889-894.
PMID: 32435401
We report the development of molecular hybrids in which a nitrate group serving as nitric oxide (NO) donor is covalently joined to σ receptor ligands to give candidates for double-targeted...
7.
Pasquinucci L, Parenti C, Ruiz-Cantero M, Georgoussi Z, Pallaki P, Cobos E, et al.
ACS Med Chem Lett
. 2020 May;
11(5):678-685.
PMID: 32435370
Modifications at the basic nitrogen of the benzomorphan scaffold allowed the development of compounds able to segregate physiological responses downstream of the receptor signaling, opening new possibilities in opioid drug...
8.
Turnaturi R, Pasquinucci L, Chiechio S, Grasso M, Marrazzo A, Amata E, et al.
ACS Chem Neurosci
. 2020 Mar;
11(7):999-1005.
PMID: 32186844
(+)-(2,6,11)- and (-)-(2,6,11)-Benzomorphan derivatives have a different binding affinity for sigma-1 (σ1R) and opioid receptors, respectively. In this study, we describe the synthesis of the (+)-enantiomer [(+)-LP1] of the benzomorphan...
9.
Romeo G, Prezzavento O, Intagliata S, Pittala V, Modica M, Marrazzo A, et al.
Eur J Med Chem
. 2019 May;
174:226-235.
PMID: 31042618
A new set of 5-chlorobenzoxazole- and 5-chlorobenzothiazole-based derivatives containing the azepane ring as a basic moiety was designed, synthesized and evaluated through binding assays to measure their affinity and selectivity...
10.
Pasquinucci L, Turnaturi R, Calo G, Pappalardo F, Ferrari F, Russo G, et al.
Eur J Med Chem
. 2019 Mar;
168:189-198.
PMID: 30822708
The pivotal role of the stereocenter at the N-substituent of the 6,7-benzomorphan scaffold was investigated combining synthetic and pharmacological approaches. 2R- and 2S-diastereoisomers of the multitarget MOR/DOR antinociceptive ligand LP2...