Lisa Matthews
Overview
Explore the profile of Lisa Matthews including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
7353
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Recent Articles
1.
Orlic-Milacic M, Rothfels K, Matthews L, Wright A, Jassal B, Shamovsky V, et al.
Database (Oxford)
. 2024 May;
2024.
PMID: 38713862
Germline and somatic mutations can give rise to proteins with altered activity, including both gain and loss-of-function. The effects of these variants can be captured in disease-specific reactions and pathways...
2.
Williams O, Ting T, Matthews L, Block G, Block T, Teresi J, et al.
Trials
. 2024 Apr;
25(1):283.
PMID: 38671470
Background: Colorectal cancer (CRC) is the second most lethal cancer in the United States (U.S.) with the highest incidence and mortality rates among African Americans (AAs) compared to other racial...
3.
Williams O, Ting T, Matthews L, Block G, Block T, Teresi J, et al.
Res Sq
. 2024 Apr;
PMID: 38659874
Background: Colorectal cancer (CRC) is the second most lethal cancer in the United States (U.S.) with the highest incidence and mortality rates among African Americans (AAs) compared to other racial...
4.
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie M, et al.
Front Immunol
. 2024 Feb;
14:1282859.
PMID: 38414974
Introduction: The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop...
5.
Tiwari K, Matthews L, May B, Shamovsky V, Orlic-Milacic M, Rothfels K, et al.
bioRxiv
. 2023 Nov;
PMID: 37986970
Appreciating the rapid advancement and ubiquity of generative AI, particularly ChatGPT, a chatbot using large language models like GPT, we endeavour to explore the potential application of ChatGPT in the...
6.
Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D672-D678.
PMID: 37941124
The Reactome Knowledgebase (https://reactome.org), an Elixir and GCBR core biological data resource, provides manually curated molecular details of a broad range of normal and disease-related biological processes. Processes are annotated...
7.
Orlic-Milacic M, Rothfels K, Matthews L, Wright A, Jassal B, Shamovsky V, et al.
bioRxiv
. 2023 Oct;
PMID: 37904913
Disease variant annotation in the context of biological reactions and pathways can provide a standardized overview of molecular phenotypes of pathogenic mutations that is amenable to computational mining and mathematical...
8.
Beavers D, Brunson T, Sanati N, Matthews L, Haw R, Shorser S, et al.
Curr Protoc
. 2023 Jul;
3(7):e845.
PMID: 37467006
Understudied or dark proteins have the potential to shed light on as-yet undiscovered molecular mechanisms that underlie phenotypes and suggest innovative therapeutic approaches for many diseases. The Reactome-IDG (Illuminating the...
9.
Brunson T, Sanati N, Matthews L, Haw R, Beavers D, Shorser S, et al.
bioRxiv
. 2023 Jun;
PMID: 37333417
Limited knowledge about a substantial portion of protein coding genes, known as "dark" proteins, hinders our understanding of their functions and potential therapeutic applications. To address this, we leveraged Reactome,...
10.
Rothfels K, Milacic M, Matthews L, Haw R, Sevilla C, Gillespie M, et al.
Curr Protoc
. 2023 Apr;
3(4):e722.
PMID: 37053306
Pathway databases provide descriptions of the roles of proteins, nucleic acids, lipids, carbohydrates, and other molecular entities within their biological cellular contexts. Pathway-centric views of these roles may allow for...