Ling-Wei Hsin
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Explore the profile of Ling-Wei Hsin including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
292
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Recent Articles
1.
Dhandabani G, Chang L, Hsieh H, Shih C, Hsin L
Org Biomol Chem
. 2024 Jan;
22(5):976-981.
PMID: 38180059
Halogenated aryl amines are a widely used chemical feedstock in the pharmaceutical and agrochemical industries. Achieving a single regioselective product from the -selective halogenation of the aryl ring is significantly...
2.
She M, Hsieh Y, Lin L, Tu C, Wu M, Hsin L, et al.
Histol Histopathol
. 2023 Dec;
39(7):903-919.
PMID: 38108436
Objectives: Aberrant serotonin (5-hydroxytryptamine, 5-HT) metabolism and neurite outgrowth were associated with abdominal pain in irritable bowel syndrome (IBS). We previously demonstrated that 5-HT receptor subtype 7 (5-HT₇) was involved...
3.
Chu J, Tseng H, Lee S, Hsu K, Hsin L, Liang R, et al.
J Enzyme Inhib Med Chem
. 2023 May;
38(1):2212326.
PMID: 37190931
Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer's disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite...
4.
Chang W, Yang Y, She M, Tu C, Lee T, Wu M, et al.
Lab Invest
. 2022 May;
102(9):1023-1037.
PMID: 35585132
Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity (VH) associated with abnormal serotonin/5-hydroxytryptamine (5-HT) metabolism and neurotrophin-dependent mucosal neurite outgrowth. The underlying mechanisms of VH remain poorly understood. We...
5.
Hsu K, Chu J, Tseng H, Liu C, Wang H, Lin T, et al.
Eur J Med Chem
. 2021 Apr;
219:113419.
PMID: 33845233
The pathogenesis of Alzheimer's disease (AD) has been associated with dysregulation of histone deacetylases (HDACs). Previously, acridine-based HDAC inhibitors have shown potential in ameliorating HDAC activity and enhancing neurite outgrowth....
6.
Peng C, Li Y, Yu C, Cheng Z, Liu J, Hsu J, et al.
Bioorg Chem
. 2021 Mar;
110:104813.
PMID: 33774493
MutT Homolog 1 (MTH1) has been proven to hydrolyze oxidized nucleotide triphosphates during DNA repair. It can prevent the incorporation of wrong nucleotides during DNA replication and mitigate cell apoptosis....
7.
Shih K, Huang Y, Yang C, Cheng M, Tien Y, Shiue C, et al.
PLoS One
. 2020 Dec;
15(12):e0243831.
PMID: 33315962
(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a positron emission tomography (PET) imaging agent for measuring the system xC- transporter activity. It has been used for the detection of various cancers and metastasis...
8.
Huang Y, Chang L, Shen H, Chen Y, Tzen K, Shiue C, et al.
Bioorg Chem
. 2020 Feb;
97:103654.
PMID: 32088418
A series of diphenylsulfide derivatives with various substitutions at the 4-position on phenyl ring A and different lengths of the 2-fluoroethoxy-substituted side-chain at the 4'-position on ring B were synthesized...
9.
Lee S, Hsin L, Su M, ChangChien C, Ku H
Pharmacol Rep
. 2019 Nov;
71(6):1281-1288.
PMID: 31683199
Background: Sepsis initiates an inflammatory response that causes widespread injury, and candidates for related myocardial depressant factors include cytokines and nitric oxide (NO). Nuclear factor kappa-B (NF-κB) stimulated by toll-like...
10.
Huang Y, Chiu M, Yen R, Tsai C, Hsieh H, Chiu C, et al.
PLoS One
. 2019 Jul;
14(7):e0217384.
PMID: 31260447
[18F]T807 is a potent tau protein imaging agent. In order to fulfill the demand from preclinical and clinical studies, we developed an automated one-pot two-step synthesis of this potent tau...