Lindsey N Kent
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Explore the profile of Lindsey N Kent including associated specialties, affiliations and a list of published articles.
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17
Citations
774
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Recent Articles
1.
Ferreira J, Kent L, McCarthy R, Butler A, Ma X, Peramsetty N, et al.
bioRxiv
. 2024 Jun;
PMID: 38853884
At the end of pregnancy, the uterus transitions from a quiescent to a highly contractile state. This is partly due to depolarization of the resting membrane potential in uterine (myometrial)...
2.
Bao J, Ma X, Kent L, Wakle-Prabagaran M, McCarthy R, England S
Biol Reprod
. 2023 Dec;
110(4):798-807.
PMID: 38134962
The large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between...
3.
Kuna M, Dhakal P, Iqbal K, Dominguez E, Kent L, Muto M, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(3):e2213622120.
PMID: 36626551
Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but...
4.
Ochoa-Rios S, OConnor I, Kent L, Clouse J, Hadjiyannis Y, Koivisto C, et al.
Mol Cell Proteomics
. 2022 Mar;
21(5):100225.
PMID: 35331917
Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation, hepatocyte injury, and fibrosis. Further, NASH is a risk factor for cirrhosis...
5.
Kent L, Li Y, Wakle-Prabagaran M, Naqvi M, Weil S, England S
Biol Reprod
. 2021 Nov;
106(3):441-448.
PMID: 34791046
Nuclear factor kappa B (NF-κB) transcriptionally regulates several genes involved in initiating uterine contractions. A key factor controlling NF-κB activity is its translocation to the nucleus. In myometrial smooth muscle...
6.
Kent L, Leone G
Nat Rev Cancer
. 2019 May;
19(6):326-338.
PMID: 31053804
The cyclin-dependent kinase (CDK)-RB-E2F axis forms the core transcriptional machinery driving cell cycle progression, dictating the timing and fidelity of genome replication and ensuring genetic material is accurately passed through...
7.
Okano-Uchida T, Kent L, Ouseph M, McCarty B, Frank J, Kladney R, et al.
Genes Dev
. 2018 Jul;
32(13-14):978-990.
PMID: 29967292
The largest subunit of the origin recognition complex (ORC1) is essential for assembly of the prereplicative complex, firing of DNA replication origins, and faithful duplication of the genome. Here, we...
8.
Huang W, Mehta D, Sif S, Kent L, Jacob S, Ghoshal K, et al.
Oncotarget
. 2017 Nov;
8(43):73757-73765.
PMID: 29088742
Hepatocellular carcinoma (HCC) is a frequent form of cancer with a poor prognosis, and environmental factors significantly contribute to the risk. Despite knowledge that a Western-style diet is a risk...
9.
Kent L, Bae S, Tsai S, Tang X, Srivastava A, Koivisto C, et al.
J Clin Invest
. 2017 Jan;
127(3):830-842.
PMID: 28134624
Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer....
10.
Kent L, Rakijas J, Pandit S, Westendorp B, Chen H, Huntington J, et al.
J Clin Invest
. 2016 Jul;
126(8):2955-69.
PMID: 27454291
E2F-mediated transcriptional repression of cell cycle-dependent gene expression is critical for the control of cellular proliferation, survival, and development. E2F signaling also interacts with transcriptional programs that are downstream of...