CITED2 is a Conserved Regulator of the Uterine-placental Interface

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2023 Jan 10

PMID 36626551

Authors

Marija Kuna

Pramod Dhakal

Khursheed Iqbal

Esteban M Dominguez

Lindsey N Kent

Masanaga Muto

Ayelen Moreno-Irusta

Keisuke Kozai

Kaela M Varberg

Hiroaki Okae

Takahiro Arima

Henry M Sucov

Michael J Soares

Affiliations

Soon will be listed here.

Abstract

Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) in rat and human trophoblast cell development. The rat and human exhibit deep hemochorial placentation. CITED2 was distinctively expressed in the junctional zone (JZ) and invasive trophoblast cells of the rat. Homozygous gene deletion resulted in placental and fetal growth restriction. Small null placentas were characterized by disruptions in the JZ, delays in intrauterine trophoblast cell invasion, and compromised plasticity. In the human placentation site, CITED2 was uniquely expressed in the extravillous trophoblast (EVT) cell column and importantly contributed to the development of the EVT cell lineage. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation.

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