Sundeep Dugar
Overview
Explore the profile of Sundeep Dugar including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
656
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Recent Articles
1.
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies
Acin-Perez R, Beninca C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, et al.
EMBO J
. 2023 Mar;
42(10):e111699.
PMID: 36912136
The maintenance of cellular function relies on the close regulation of adenosine triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is induced by loss of proton...
2.
Navarrete-Yanez V, Garate-Carrillo A, Ayala M, Rodriguez-Castaneda A, Mendoza-Lorenzo P, Ceballos G, et al.
Food Funct
. 2021 Apr;
12(8):3504-3515.
PMID: 33900336
Consumption of (-)-epicatechin (Epi), a cacao flavanol improves cognition. The aim was to compare the effects of (-)-Epi or its stereoisomer (+)-Epi on mouse frontal cortex-dependent short-term working memory and...
3.
Tran A, Sullivan S, Chan L, Yin Y, Sun W, Fang Z, et al.
Front Oncol
. 2021 Mar;
10:624498.
PMID: 33659215
SPR965 is an inhibitor of PI3K and mTOR C1/C2 and has demonstrated anti-tumorigenic activity in a variety of solid tumors. We sought to determine the effects of SPR965 on cell...
4.
McDonald C, Ramirez-Sanchez I, Oskarsson B, Joyce N, Aguilar C, Nicorici A, et al.
Muscle Nerve
. 2020 Oct;
63(2):239-249.
PMID: 33125736
Introduction: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult patients with Becker muscular dystrophy (BMD). Methods: Seven participants received (-)-epicatechin 50 ...
5.
Zhao X, Kong W, Tucker K, Staley A, Fan Y, Sun W, et al.
Am J Transl Res
. 2020 Sep;
12(8):4264-4276.
PMID: 32913503
Paclitaxel is one of the most effective and widely used agents in treating a variety of cancers, including endometrial cancer. Because of its poor solubility in water, the current intravenous...
6.
Mahajan D, Sen S, Kuila B, Sharma A, Arora R, Sagar M, et al.
J Med Chem
. 2020 Sep;
63(19):11121-11130.
PMID: 32897703
Herein, we report the identification and preclinical profile of a lead compound , () as an equally potent dual inhibitor of PI3Kα and mTOR kinases. exhibits an EC of low...
7.
Qureshi M, Patterson M, Clark V, Johnson J, Moutvic M, Driscoll S, et al.
J Inherit Metab Dis
. 2020 Jul;
44(2):502-514.
PMID: 32677106
Background: (+)-Epicatechin (EPI) induces mitochondrial biogenesis and antioxidant metabolism in muscle fibers and neurons. We aimed to evaluate safety and efficacy of (+)-EPI in pediatric subjects with Friedreich's ataxia (FRDA)....
8.
Dugar S, Villarreal F, Hollinger F, Mahajan D, Ramirez-Sanchez I, Moreno-Ulloa A, et al.
Pharmacol Res
. 2019 Nov;
151:104540.
PMID: 31722227
Currently, there is great interest in identifying endogenous (i.e. physiological) stimulators of mitochondrial biogenesis (MB), in particular, those that may mediate the effects of exercise. The molecular size of the...
9.
Moreno-Ulloa A, Najera-Garcia N, Hernandez M, Ramirez-Sanchez I, Taub P, Su Y, et al.
Food Funct
. 2017 Nov;
9(1):307-319.
PMID: 29171848
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate that the (+) stereoisomer form may be more potent. We evaluated in a preliminary manner,...
10.
Gutierrez-Salmean G, Meaney E, Lanaspa M, Cicerchi C, Johnson R, Dugar S, et al.
Int J Cardiol
. 2016 Aug;
223:500-506.
PMID: 27552564
Background: Cardiometabolic disruptions such as insulin resistance, obesity, high blood pressure, hyperglycemia, and dyslipidemias, are known to increase the risk for cardiovascular and metabolic diseases such as type 2 diabetes...