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Lily Q Dong

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Articles 66
Citations 2634
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Recent Articles
1.
Morales D, Ryu J, Wei C, Hadley J, Smith M, Bai J, et al.
Diabetologia . 2024 Nov; 68(3):615-628. PMID: 39589509
Aims/hypothesis: Upregulation of serum leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in diet-induced obesity and metabolic disorders. However, its specific hormonal actions remain unclear. This study aimed to determine whether...
2.
El-Araby R, Tu Q, Xie Y, Aboushousha T, Li Z, Xu X, et al.
Aging Dis . 2024 Jun; 16(2):1059-1079. PMID: 38916734
Type 2 diabetes (T2D) is a widespread health condition both in the United States and around the world, with insulin resistance playing a critical role in its development. Effective treatment...
3.
Xiao Y, Wang Y, Ryu J, Liu W, Zou H, Zhang R, et al.
Diabetologia . 2023 Mar; 66(6):1142-1155. PMID: 36917279
Aims/hypothesis: Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-β is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum...
4.
Parthasarathy R, Hagglof T, Hadley J, McLennan A, Mattke A, Dudley E, et al.
Front Immunol . 2021 Dec; 12:758407. PMID: 34956189
Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production. While disease mechanisms for...
5.
He S, Ryu J, Liu J, Luo H, Lv Y, Langlais P, et al.
J Clin Invest . 2021 Nov; 131(24). PMID: 34730111
Dysregulation in adipokine biosynthesis and function contributes to obesity-induced metabolic diseases. However, the identities and functions of many of the obesity-induced secretory molecules remain unknown. Here, we report the identification...
6.
Meng W, Xiao T, Liang X, Wen J, Peng X, Wang J, et al.
JCI Insight . 2021 Jul; 6(17). PMID: 34264867
A dynamically regulated microenvironment, which is mediated by crosstalk between adipocytes and neighboring cells, is critical for adipose tissue homeostasis and function. However, information on key molecules and/or signaling pathways...
7.
Ryu J, Hadley J, Li Z, Dong F, Xu H, Xin X, et al.
Diabetes . 2021 Jun; 70(6):1303-1316. PMID: 34162682
Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in insulin target tissues including liver. While the insulin-sensitizing function of adiponectin has been extensively investigated, the precise mechanism by...
8.
Lin Y, Dong L
Proc Jpn Acad Ser B Phys Biol Sci . 2020 Oct; 96(8):364-371. PMID: 33041270
Adiponectin is an adipokine that can exert a regulatory function on bone metabolism. However, there are many contradictions between clinical and pre-clinical studies on adiponectin. APPL1 is an adaptor protein...
9.
Qiu W, Wu H, Hu Z, Wu X, Tu M, Fang F, et al.
Br J Pharmacol . 2020 Sep; 178(2):280-297. PMID: 32986862
Background And Purpose: Adiponectin (APN) is an adipokine secreted from adipocytes that binds to APN receptors AdipoR1 and AdipoR2 and exerts an anti-inflammatory response through mechanisms not fully understood. There...
10.
Cersosimo E, Xu X, Terasawa T, Dong L
Mol Biol Rep . 2020 Aug; 47(9):6561-6572. PMID: 32789574
After confirmation of the presence of adiponectin (ADPN) receptors and intra-cellular binding proteins in coronary artery smooth muscle cells (VSMC), we tested the hypotheses that, in acute insulin resistance: (i)...