Lillian B Sutherland
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Explore the profile of Lillian B Sutherland including associated specialties, affiliations and a list of published articles.
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21
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5841
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Recent Articles
1.
Millay D, Sutherland L, Bassel-Duby R, Olson E
Genes Dev
. 2014 Aug;
28(15):1641-6.
PMID: 25085416
Regeneration of injured adult skeletal muscle involves fusion of activated satellite cells to form new myofibers. Myomaker is a muscle-specific membrane protein required for fusion of embryonic myoblasts, but its...
2.
Velasquez L, Sutherland L, Liu Z, Grinnell F, Kamm K, Schneider J, et al.
Proc Natl Acad Sci U S A
. 2013 Oct;
110(42):16850-5.
PMID: 24082095
Myocardin-related transcription factors (MRTFs) regulate cellular contractility and motility by associating with serum response factor (SRF) and activating genes involved in cytoskeletal dynamics. We reported previously that MRTF-A contributes to...
3.
Xin M, Kim Y, Sutherland L, Murakami M, Qi X, McAnally J, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(34):13839-44.
PMID: 23918388
The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the neonatal heart can regenerate owing to sustained...
4.
Millay D, ORourke J, Sutherland L, Bezprozvannaya S, Shelton J, Bassel-Duby R, et al.
Nature
. 2013 Jul;
499(7458):301-5.
PMID: 23868259
Fusion of myoblasts is essential for the formation of multi-nucleated muscle fibres. However, the identity of muscle-specific proteins that directly govern this fusion process in mammals has remained elusive. Here...
5.
Grueter C, Van Rooij E, Johnson B, DeLeon S, Sutherland L, Qi X, et al.
Cell
. 2012 May;
149(3):671-83.
PMID: 22541436
Obesity, type 2 diabetes, and heart failure are associated with aberrant cardiac metabolism. We show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex,...
6.
Xin M, Kim Y, Sutherland L, Qi X, McAnally J, Schwartz R, et al.
Sci Signal
. 2011 Oct;
4(196):ra70.
PMID: 22028467
The Hippo signaling pathway regulates growth of the heart and other tissues. Hippo pathway kinases influence the activity of various targets, including the transcriptional coactivator Yap, but the specific role...
7.
Small E, Sutherland L, Rajagopalan K, Wang S, Olson E
Circ Res
. 2010 Oct;
107(11):1336-44.
PMID: 20947829
Rationale: Establishment of a functional vasculature requires the interconnection and remodeling of nascent blood vessels. Precise regulation of factors that influence endothelial cell migration and function is essential for these...
8.
Small E, Thatcher J, Sutherland L, Kinoshita H, Gerard R, Richardson J, et al.
Circ Res
. 2010 Jun;
107(2):294-304.
PMID: 20558820
Rationale: Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis...
9.
Small E, ORourke J, Moresi V, Sutherland L, McAnally J, Gerard R, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(9):4218-23.
PMID: 20142475
microRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNA targets. In a screen for miRNAs regulated by myocardin-related transcription factor-A (MRTF-A), a coactivator...
10.
Van Rooij E, Quiat D, Johnson B, Sutherland L, Qi X, Richardson J, et al.
Dev Cell
. 2009 Nov;
17(5):662-73.
PMID: 19922871
Myosin is the primary regulator of muscle strength and contractility. Here we show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intronic microRNAs (miRNAs), which, in turn, control...