Liliane C Broye
Overview
Explore the profile of Liliane C Broye including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
492
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Recent Articles
1.
Boulay G, Broye L, Dong R, Iyer S, Sanalkumar R, Xing Y, et al.
Nat Commun
. 2024 Aug;
15(1):7460.
PMID: 39198430
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles...
2.
Bakaric A, Cironi L, Praz V, Sanalkumar R, Broye L, Favre-Bulle K, et al.
Cancers (Basel)
. 2024 Jan;
16(2).
PMID: 38275898
CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the...
3.
Moller E, Praz V, Rajendran S, Dong R, Cauderay A, Xing Y, et al.
Nat Commun
. 2022 Apr;
13(1):2267.
PMID: 35477713
Oncogenic fusion proteins generated by chromosomal translocations play major roles in cancer. Among them, fusions between EWSR1 and transcription factors generate oncogenes with powerful chromatin regulatory activities, capable of establishing...
4.
Jerby-Arnon L, Neftel C, Shore M, Weisman H, Mathewson N, McBride M, et al.
Nat Med
. 2021 Jan;
27(2):289-300.
PMID: 33495604
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18-SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer-immune interplay in SyS using an...
5.
Boulay G, Cironi L, Garcia S, Rengarajan S, Xing Y, Lee L, et al.
Life Sci Alliance
. 2020 Dec;
4(2).
PMID: 33361335
Synovial sarcoma (SyS) is an aggressive mesenchymal malignancy invariably associated with the chromosomal translocation t(X:18; p11:q11), which results in the in-frame fusion of the BAF complex gene to one of...
6.
Boulay G, Volorio A, Iyer S, Broye L, Stamenkovic I, Riggi N, et al.
Genes Dev
. 2018 Jul;
32(15-16):1008-1019.
PMID: 30042132
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the...
7.
Boulay G, Sandoval G, Riggi N, Iyer S, Buisson R, Naigles B, et al.
Cell
. 2017 Aug;
171(1):163-178.e19.
PMID: 28844694
Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, which is mutated in over 20% of...
8.
Oudin M, Jonas O, Kosciuk T, Broye L, Guido B, Wyckoff J, et al.
Cancer Discov
. 2016 Jan;
6(5):516-31.
PMID: 26811325
Unlabelled: Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN gradients elicit directional movement of...